Evolutionary Dynamics and Dissemination Pattern of the SARS-CoV-2 Lineage B.1.1.33 During the Early Pandemic Phase in Brazil.
Evolutionary Dynamics and Dissemination Pattern of the SARS-CoV-2 Lineage B.1.1.33 During the Early Pandemic Phase in Brazil.
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DOI：
10.3389/fmicb.2020.615280
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发表时间：
2020
影响因子：
5.2
通讯作者：
Siqueira MM
中科院分区：
文献类型：
--
作者：
Resende PC;Delatorre E;Gräf T;Mir D;Motta FC;Appolinario LR;da Paixão ACD;Mendonça ACDF;Ogrzewalska M;Caetano B;Wallau GL;Docena C;Dos Santos MC;de Almeida Ferreira J;Sousa Junior EC;da Silva SP;Fernandes SB;Vianna LA;Souza LDC;Ferro JFG;Nardy VB;Santos CA;Riediger I;do Carmo Debur M;Croda J;Oliveira WK;Abreu A;Bello G;Siqueira MM
先前的一项研究表明，大多数严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) 巴西毒株属于 2020 年 2 月下旬左右从欧洲引入的三个本地进化枝。在这里，我们更详细地调查了主要且传播最广泛的 SARS-CoV-2 巴西谱系 B.1.1.33 的起源。我们恢复了2020年2月29日至4月31日从巴西13个州收集的190个完整病毒基因组，并将它们与全球收集的其他B.1.1基因组结合起来。我们的基因组调查证实，B.1.1.33 谱系在巴西各州的社区病毒传播中所占比例有所不同，从伯南布哥州所有 SARS-CoV-2 基因组的 2% 到里约热内卢的 80%。我们在一些南美洲国家检测到谱系 B.1.1.33 的患病率中等（5-18%），而在北美、欧洲和大洋洲的患病率非常低（<1%）。我们的研究表明，谱系 B.1.1.33 是从一个祖先分支进化而来的，这里指定为 B.1.1.33 样，它携带两个 B.1.1.33 突触突变之一。类似 B.1.1.33 的谱系可能是从欧洲引入的，或者于 2020 年 2 月上旬在巴西出现，几周后产生了 B.1.1.33 谱系。这些 SARS-CoV-2 谱系可能在 2020 年 2 月期间传播，并在 3 月中旬巴西实施航空旅行限制之前到达巴西所有地区和世界多个国家。我们的系统动力学分析还表明，公共卫生干预措施对控制里约热内卢谱系 B.1.1.33 的扩张部分有效，因为其中位有效繁殖数 (Re) 在 2020 年 3 月期间大幅减少了约 66%，但未能降至 1 以下。对谱系 B.1.1.33 进行连续基因组监测可能会提供有关巴西一些州的流行病动态和公共卫生干预措施有效性的宝贵信息。
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020. Here we investigated in more detail the origin of the major and most widely disseminated SARS-CoV-2 Brazilian lineage B.1.1.33. We recovered 190 whole viral genomes collected from 13 Brazilian states from February 29 to April 31, 2020 and combined them with other B.1.1 genomes collected globally. Our genomic survey confirms that lineage B.1.1.33 is responsible for a variable fraction of the community viral transmissions in Brazilian states, ranging from 2% of all SARS-CoV-2 genomes from Pernambuco to 80% of those from Rio de Janeiro. We detected a moderate prevalence (5–18%) of lineage B.1.1.33 in some South American countries and a very low prevalence (<1%) in North America, Europe, and Oceania. Our study reveals that lineage B.1.1.33 evolved from an ancestral clade, here designated B.1.1.33-like, that carries one of the two B.1.1.33 synapomorphic mutations. The B.1.1.33-like lineage may have been introduced from Europe or arose in Brazil in early February 2020 and a few weeks later gave origin to the lineage B.1.1.33. These SARS-CoV-2 lineages probably circulated during February 2020 and reached all Brazilian regions and multiple countries around the world by mid-March, before the implementation of air travel restrictions in Brazil. Our phylodynamic analysis also indicates that public health interventions were partially effective to control the expansion of lineage B.1.1.33 in Rio de Janeiro because its median effective reproductive number (Re) was drastically reduced by about 66% during March 2020, but failed to bring it to below one. Continuous genomic surveillance of lineage B.1.1.33 might provide valuable information about epidemic dynamics and the effectiveness of public health interventions in some Brazilian states.
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影响因子：
64.5
作者：
Fauver, Joseph R.;Petrone, Mary E.;Grubaugh, Nathan D.
通讯作者：
Grubaugh, Nathan D.
影响因子：
10.7
作者：
Dellicour S;Durkin K;Hong SL;Vanmechelen B;Martí-Carreras J;Gill MS;Meex C;Bontems S;André E;Gilbert M;Walker C;Maio N;Faria NR;Hadfield J;Hayette MP;Bours V;Wawina-Bokalanga T;Artesi M;Baele G;Maes P
通讯作者：
Maes P
影响因子：
56.9
作者：
Gonzalez-Reiche, Ana S.;Hernandez, Matthew M.;van Bakel, Harm
通讯作者：
van Bakel, Harm
DOI：
10.1002/cjs.5550360302
发表时间：
2008-09-01
影响因子：
0.6
作者：
Ferreira, Marco A. R.;Suchard, Marc A.
通讯作者：
Suchard, Marc A.
影响因子：
56.9
作者：
Deng, Xianding;Gu, Wei;Chiu, Charles Y.
通讯作者：
Chiu, Charles Y.