Translational approaches to influence sleep and arousal.
Translational approaches to influence sleep and arousal.
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影响睡眠和觉醒的转化方法
DOI：
10.1016/j.brainresbull.2022.05.002
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发表时间：
2022-07
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
睡眠障碍在社会中广泛存在，在军人和退伍军人中普遍存在。睡眠和觉醒机制障碍在精神分裂症、创伤后应激障碍、焦虑和情感障碍、创伤性脑损伤、痴呆和物质使用障碍等神经精神疾病中很常见。睡眠障碍会加剧自杀意念，这是退伍军人和普通人群的主要担忧。这些障碍损害生活质量，影响人际关系，降低工作效率，加重其他疾病的临床特征，并损害恢复。因此，需要改善睡眠和调节觉醒的方法。对控制睡眠和觉醒的大脑回路的基础科学研究导致最近批准了针对食欲素/下丘脑泌素和组胺系统的新药，补充了影响GABAA受体和单胺能系统的现有药物。调节睡眠和觉醒的非侵入性脑刺激技术是安全的，并显示出潜力，但需要进一步发展才能广泛应用。侵入性病毒载体和深部脑刺激方法也处于起步阶段，但可用于调节严重神经和精神疾病的睡眠和觉醒。行为，药理学，非侵入性脑刺激和细胞特异性侵入性方法表明，有可能选择性地影响觉醒，睡眠启动，睡眠维持或睡眠阶段的特定现象，如睡眠纺锤波或慢波活动。这些操作可以通过促进睡眠对记忆巩固、清除有毒代谢物、代谢和免疫功能的恢复作用以及通过减少过度觉醒来积极影响广泛的神经和精神疾病的治疗。
Sleep disorders are widespread in society and are prevalent in military personnel and in Veterans. Disturbances of sleep and arousal mechanisms are common in neuropsychiatric disorders such as schizophrenia, post-traumatic stress disorder, anxiety and affective disorders, traumatic brain injury, dementia, and substance use disorders. Sleep disturbances exacerbate suicidal ideation, a major concern for Veterans and in the general population. These disturbances impair quality of life, affect interpersonal relationships, reduce work productivity, exacerbate clinical features of other disorders, and impair recovery. Thus, approaches to improve sleep and modulate arousal are needed. Basic science research on the brain circuitry controlling sleep and arousal led to the recent approval of new drugs targeting the orexin/hypocretin and histamine systems, complementing existing drugs which affect GABAA receptors and monoaminergic systems. Non-invasive brain stimulation techniques to modulate sleep and arousal are safe and show potential but require further development to be widely applicable. Invasive viral vector and deep brain stimulation approaches are also in their infancy but may be used to modulate sleep and arousal in severe neurological and psychiatric conditions. Behavioral, pharmacological, non-invasive brain stimulation and cell-specific invasive approaches covered here suggest the potential to selectively influence arousal, sleep initiation, sleep maintenance or sleep-stage specific phenomena such as sleep spindles or slow wave activity. These manipulations can positively impact the treatment of a wide range of neurological and psychiatric disorders by promoting the restorative effects of sleep on memory consolidation, clearance of toxic metabolites, metabolism, and immune function and by decreasing hyperarousal.
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影响因子：
16.6
作者：
Bandarabadi M;Herrera CG;Gent TC;Bassetti C;Schindler K;Adamantidis AR
通讯作者：
Adamantidis AR
影响因子：
16.6
作者：
Anaclet C;Pedersen NP;Ferrari LL;Venner A;Bass CE;Arrigoni E;Fuller PM
通讯作者：
Fuller PM
影响因子：
3.3
作者：
Arrigoni, E.;Chamberlin, N. L.;McCarley, R. W.
通讯作者：
McCarley, R. W.
影响因子：
64.8
作者：
Adamantidis, Antoine R.;Zhang, Feng;De Lecea, Luis
通讯作者：
De Lecea, Luis
影响因子：
3.1
作者：
Achermann, P;Borbély, AA
通讯作者：
Borbély, AA