Salvia miltiorrhiza in thorax and abdomainal organ fibrosis: A review of its pharmacology.
Salvia miltiorrhiza in thorax and abdomainal organ fibrosis: A review of its pharmacology.
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丹参在胸腹器官纤维化中的作用：药理学综述
DOI：
10.3389/fphar.2022.999604
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
器官纤维化是一种常见的病理变化，最终导致器官衰竭，其涉及实质细胞的破坏、间充质细胞的激活和免疫细胞的失衡。近年来，虽然在了解器官纤维化的发病机制和治疗方面取得了一些突破，但没有注册药物可以直接靶向纤维化过程，这构成了一个重大的生物医学挑战。丹参（Salvia miltiorrhiza，SM）是我国著名的药用植物，具有抗氧化、抗心肌梗死、抗纤维化、抗炎、抗肿瘤等药理作用，被广泛应用。越来越多的研究表明，丹参通过其多种生物活性成分在体内和体外抗器官纤维化中发挥重要作用。本文就丹参及其有效成分在肝、肺、肾、心纤维化中的植物化学和药理作用机制进行综述，以期为临床治疗胸、肺脏器纤维化疾病提供参考。
Organ fibrosis is a common pathological change that finally results in organ failure, which involves the destruction of parenchyma cells, the activation of mesenchymal cells and the imbalance of immunological cells. In recent years, although some breakthroughs have been made in understanding the pathogenesis and therapeutics of organ fibrosis, no registered drugs could directly target the fibrotic process, which constitutes a major biomedical challenge. Salvia miltiorrhiza (SM) is a well-known medicinal plant in China, which has been widely applied because of its pharmacological effects on anti-oxidative, anti-myocardial infarction, anti-fibrotic, anti-inflammatory, and anti-neoplastic properties. Accumulated evidence suggested that SM played critical roles against organ fibrosis in vivo and in vitro experiments by its multiple biological compounds. In this review, we discussed the recent advances on the phytochemistry and pharmacological mechanisms of SM and its active ingredients in liver, lung, kidney, and heart fibrosis, which might help to promote the treatment of fibrotic diseases in thorax and abdomainal viscera in clinic.
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影响因子：
7.2
作者：
Ahn, Young-Min;Kim, Su Kang;Lee, Byung-Cheol
通讯作者：
Lee, Byung-Cheol
丹参酮 IIA 通过调节氧化还原稳态和谷氨酰胺分解激活核因子红细胞 2 相关因子 2 抑制肺纤维化
影响因子：
6.6
作者：
An, Lin;Peng, Li-Ying;Chen, Jun
通讯作者：
Chen, Jun
DOI：
10.3390/molecules18022122
发表时间：
2013-02-06
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Parajuli DR;Park EJ;Che XH;Jiang WY;Kim YC;Sohn DH;Lee SH
通讯作者：
Lee SH
DOI：
10.3390/molecules15096365
发表时间：
2010-09-09
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Gallo M;Ferracane R;Graziani G;Ritieni A;Fogliano V
通讯作者：
Fogliano V
影响因子：
5.4
作者：
Han, Cong;Jiang, Yue-hua;Liu, Yao
通讯作者：
Liu, Yao