Resident vascular progenitor cells--diverse origins, phenotype, and function.
Resident vascular progenitor cells--diverse origins, phenotype, and function.
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DOI：
10.1007/s12265-010-9248-9
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发表时间：
2011-04
影响因子：
3.4
通讯作者：
Simari, Robert D.
中科院分区：
文献类型：
--
作者：
Psaltis, Peter J.;Harbuzariu, Adriana;Delacroix, Sinny;Holroyd, Eric W.;Simari, Robert D.
关键词：
血管对器官发生和组织稳态的基本贡献反映在血管壁完整性丧失对产前和产后健康的重大影响上。在损伤后的新血管形成和血管壁重塑期间，血管细胞生长和替换的动态性质破坏了血管主要包含成熟的终末分化细胞群的传统印象。最近的发现已经证实了在脉管系统的壁层内存在用于血管和非血管后代的不同干/祖细胞。在胚胎发生过程中，这包括从发育中的背主动脉出现永久性造血干细胞和多能成中血管细胞。也已经从成熟的成人血管中鉴定和分离出祖细胞，其显示出内皮、平滑肌、造血和间充质分化的可变能力。目前，这些不同的血管壁祖细胞的特征仍然有些初步，但有证据表明，它们的组成性居住在有组织的隔间在血管壁，最引人注目的是在图尼卡外膜。本文综述了在发育和成年期大血管和微血管中发现的干细胞/祖细胞的谱，并考虑了局部血管壁干细胞生态位在心血管和其他疾病发病机制和治疗中的意义。
The fundamental contributions that blood vessels make toward organogenesis and tissue homeostasis are reflected by the considerable ramifications that loss of vascular wall integrity has on pre- and postnatal health. During both neovascularization and vessel wall remodeling after insult, the dynamic nature of vascular cell growth and replacement vitiates traditional impressions that blood vessels contain predominantly mature, terminally-differentiated cell populations. Recent discoveries have verified the presence of diverse stem/progenitor cells for both vascular and non-vascular progeny within the mural layers of the vasculature. During embryogenesis, this encompasses the emergence of definitive hematopoietic stem cells and multipotent mesoangioblasts from the developing dorsal aorta. Ancestral cells have also been identified and isolated from mature, adult blood vessels, showing variable capacity for endothelial, smooth muscle, hematopoietic and mesenchymal differentiation. At present, the characterization of these different vascular wall progenitors remains somewhat rudimentary, but there is evidence for their constitutive residence within organized compartments in the vessel wall, most compellingly in the tunica adventitia. This review overviews the spectrum of resident stem/progenitor cells that have been documented in macro- and micro-vessels during developmental and adult life and considers the implications for a local, vascular wall stem cell niche(s) in the pathogenesis and treatment of cardiovascular and other diseases.
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影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
37.8
作者：
Bentzon, Jacob F.;Sondergaard, Claus S.;Falk, Erling
通讯作者：
Falk, Erling
DOI：
10.1161/01.atv.0000247243.48542.9d
发表时间：
2006-12-01
影响因子：
8.7
作者：
Bentzon, Jacob F.;Weile, Charlotte;Falk, Erling
通讯作者：
Falk, Erling
DOI：
10.1073/pnas.0907622106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Bearzi, Claudia;Leri, Annarosa;Anversa, Piero
通讯作者：
Anversa, Piero