Changes in resting neural connectivity during propofol sedation.
Changes in resting neural connectivity during propofol sedation.
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DOI：
10.1371/journal.pone.0014224
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发表时间：
2010-12-02
期刊：
影响因子：
3.7
通讯作者：
Menon DK
中科院分区：
文献类型：
--
作者：
Stamatakis EA;Adapa RM;Absalom AR;Menon DK
默认模式网络由一组功能连接的大脑区域（后扣带回、内侧前额叶皮层和双侧顶叶皮层）组成，在“无任务”条件下在功能成像研究中最活跃。有人认为后扣带皮层在意识/意识中很重要，但之前对后扣带皮层和其他大脑区域在镇静和麻醉过程中静息相互作用的研究产生了不一致的结果。我们检查了不同意识水平下后扣带回的连接性。 “无任务”功能磁共振成像 (BOLD) 数据是在清醒状态下、在麻醉剂异丙酚诱导下处于低度和中度镇静状态的健康志愿者身上收集的。我们的数据显示，镇静期间后扣带回的连接发生变化，包括传统上不被认为是默认模式网络一部分的区域，例如运动/体感皮层、丘脑前核和网状激活系统。这种神经解剖学特征类似于非快速眼动睡眠，并且可能是一个系统的证据，该系统会减少其可辨别状态并在镇静状态下切换到更刻板的放电模式。
The default mode network consists of a set of functionally connected brain regions (posterior cingulate, medial prefrontal cortex and bilateral parietal cortex) maximally active in functional imaging studies under “no task” conditions. It has been argued that the posterior cingulate is important in consciousness/awareness, but previous investigations of resting interactions between the posterior cingulate cortex and other brain regions during sedation and anesthesia have produced inconsistent results. We examined the connectivity of the posterior cingulate at different levels of consciousness. “No task” fMRI (BOLD) data were collected from healthy volunteers while awake and at low and moderate levels of sedation, induced by the anesthetic agent propofol. Our data show that connectivity of the posterior cingulate changes during sedation to include areas that are not traditionally considered to be part of the default mode network, such as the motor/somatosensory cortices, the anterior thalamic nuclei, and the reticular activating system. This neuroanatomical signature resembles that of non-REM sleep, and may be evidence for a system that reduces its discriminable states and switches into more stereotypic patterns of firing under sedation.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
9.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
CRICK, F;KOCH, C
通讯作者：
KOCH, C
影响因子：
3.2
作者：
Greicius, MD;Menon, V
通讯作者：
Menon, V