Marginal association between SNP rs2046571 of the HAS2 gene and Parkinson's disease in the Chinese female population
Marginal association between SNP rs2046571 of the HAS2 gene and Parkinson's disease in the Chinese female population
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HAS2基因SNP rs2046571与中国女性人群帕金森病的边际关联
DOI：
10.1016/j.neulet.2013.07.031
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Y. Yuan, B.S. Tang, R.L. Yu, K. Li, Z.Y. Lv, X.X.
中科院分区：
文献类型：
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作者：
Y. Yuan, B.S. Tang, R.L. Yu, K. Li, Z.Y. Lv, X.X.
Recent GWASs have implicated many novel SNPs in the development of Parkinson's disease (PD). Single nucleotide polymorphism (SNP) rs2046571 of the HSA2 (encoding hyaluronan synthase 2) was reported to have marginal association with PD. Herein, we conducted a case–control study to evaluate the possible association between SNP rs2046571 and PD in Chinese. All subjects (1043 PD patient and 1044 normal control) were successfully genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. No statistically significant difference in genotype frequency between cases and controls was observed (P= 0.074), no statistically significant difference in genotype frequency between early-onset and late-onset was observed (P= 0.264 andP= 0.120, respectively). No statistically significant difference in genotype frequency between male cases and controls (P= 0.108). But surprisingly, there was statistically marginal significant difference in genotype frequency between female cases and controls (P= 0.042). Our findings suggested that rs2046571 of the HSA2 has marginal association with PD in Chinese population.
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DOI：
10.1084/jem.20001858
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Termeer C;Benedix F;Sleeman J;Fieber C;Voith U;Ahrens T;Miyake K;Freudenberg M;Galanos C;Simon JC
通讯作者：
Simon JC
影响因子：
0.9
作者：
Stuhlmeier, Karl M.
通讯作者：
Stuhlmeier, Karl M.
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
30.8
作者：
Satake, Wataru;Nakabayashi, Yuko;Toda, Tatsushi
通讯作者：
Toda, Tatsushi
影响因子：
30.8
作者：
通讯作者：
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