Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.

Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.
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DOI:
10.1021/ja3019143
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发表时间:
2012-04-25
影响因子:
15
通讯作者:
Thayumanavan, S.
Thayumanavan, S.
中科院分区:
化学1区
文献类型:
--
作者:
Gonzalez-Toro, Daniella C.;Ryu, Ja-Hyoung;Chacko, Reuben T.;Zhuang, Jiaming;Thayumanavan, S.

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Supramolecular nanoassemblies, which are capable of binding and delivering either lipophilic small molecules or hydrophilic molecules, are of great interest. Concurrently binding and delivering this combination of molecules is cumbersome, because of the opposing supramolecular host requirements. We describe the development of a versatile nanoassembly system that is capable of binding and delivering both, a protein and a lipophilic small molecule, simultaneously inside the cells.
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