Identification and sequence of seventy-nine new transcripts expressed in hemocytes of Ciona intestinalis, three of which may be involved in characteristic cell-cell communication.
Identification and sequence of seventy-nine new transcripts expressed in hemocytes of Ciona intestinalis, three of which may be involved in characteristic cell-cell communication.
复制标题
玻璃海鞘血细胞中表达的 79 个新转录本的鉴定和测序，其中 3 个可能参与特征性细胞间通讯。
作者：
D. Terajima;S. Yamada;Ryuji Uchino;S. Ikawa;M. Ikeda;K. Shida;Y. Arai;Hong;N. Satoh;M. Satake
海鞘是研究脊索动物门的身体规划原则和宿主防御机制的有用实验动物。为了实现这一目标，已经开展了玻璃海鞘的基因组和cDNA/EST计划。使用cDNA和EST来自玻璃海鞘血细胞，我们确定了79个可能的血细胞优先转录本，并确定每个克隆的cDNA序列。预测了每个编码多肽的氨基酸序列。在这些cDNA中，我们确定了三个转录本，可能参与特征细胞-细胞通信在玻璃海鞘。这些转录本编码富含亮氨酸重复序列的RP 105样、IL-17受体/类似于FGF样表达和tunmr坏死因子家族的外胚层发育不良样多肽，并且它们在血细胞中大量表达。
Ascidian is a useful experimental animal for studying body planning principles and host defense mechanisms employed by the phylum chordata. Toward this goal, genome and cDNA/EST projects of Ciona intestinalis have been undertaken. Using cDNAs and ESTs derived from Ciona hemocytes, we identified 79 possible hemocyte-preferential transcripts and determined the cDNA sequence of each clone. The amino acid sequence of each encoded polypeptide was predicted as well. Among these cDNAs, we identified three transcripts that may be involved in characteristic cell-cell communication in Ciona. These transcripts encoded leucine-rich repeat-containing RP105-like, IL-17 receptor/similar expression to FGF-like, and ectodysplasin-like polypeptide of the tunmr necrosis factor famlly, and they are expressed abundantly in hemocytes.
影响因子：
16
作者：
Medzhitov, R;Preston-Hurlburt, P;Janeway, CA
通讯作者：
Janeway, CA