Vasculature of the Suprachiasmatic Nucleus: Pathways for Diffusible Output Signals.
Vasculature of the Suprachiasmatic Nucleus: Pathways for Diffusible Output Signals.
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DOI：
10.1177/07487304231189537
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发表时间：
2023-12
影响因子：
3.5
通讯作者：
Silver, Rae
中科院分区：
文献类型：
--
作者：
Yao, Yifan;Green, Isabella K.;Taub, Alana B.;Tazebay, Ruya;LeSauter, Joseph;Silver, Rae
关键词：
移植研究明确证明视交叉上核（SCN）产生可维持昼夜运动节律的扩散信号。小鼠大脑的视交叉上核和终板血管器官之间存在一条血管门脉通路。门脉通路使低浓度的神经分泌物能够到达特定的局部目标，而不会在体循环中稀释。为了探索 SCN 脉管系统和 SCN 神经分泌物可能到达门脉血管的毛细血管，我们研究了核心和外壳 SCN 的血管 (BV)。 SCN 的动脉供应因动物而异，并且在某些动物中，两侧之间存在差异。吻侧 SCN 由垂体上动脉 (SHpA) 或大脑前动脉或前交通动脉的分支供血。尾部 SCN 始终由 SHpA 提供。头侧SCN由视前静脉引流，而尾侧由基底静脉引流，引流血管的侧向性有所不同。此外，核心和外壳 SCN 区域的几个关键特征有所不同：根据共焦图像测量，外壳中的中位 BV 直径明显小于核心，并且 iDISCO 透明组织中也出现类似的趋势。在清除的组织中，壳中的整个 BV 长度密度和表面积密度明显大于核。最后，壳中的毛细管长度密度也大于芯中的毛细管长度密度。结果提出了三个假设：首先，头侧和尾侧 SCN 的不同动脉和静脉系统可能导致 SCN 网络中观察到的代谢和神经活动的体内变化。其次，视交叉上核外壳的致密毛细血管能够很好地传输血液信号。最后，SCN 血管供应和引流的变化可能导致动物间的差异。
Transplant studies demonstrate unequivocally that the suprachiasmatic nucleus (SCN) produces diffusible signals that can sustain circadian locomotor rhythms. There is a vascular portal pathway between the SCN and the organum vasculosum of the lamina terminalis in mouse brain. Portal pathways enable low concentrations of neurosecretions to reach specialized local targets without dilution in the systemic circulation. To explore the SCN vasculature and the capillary vessels whereby SCN neurosecretions might reach portal vessels, we investigated the blood vessels (BVs) of the core and shell SCN. The arterial supply of the SCN differs among animals, and in some animals, there are differences between the 2 sides. The rostral SCN is supplied by branches from either the superior hypophyseal artery (SHpA) or the anterior cerebral artery or the anterior communicating artery. The caudal SCN is consistently supplied by the SHpA. The rostral SCN is drained by the preoptic vein, while the caudal is drained by the basal vein, with variations in laterality of draining vessels. In addition, several key features of the core and shell SCN regions differ: Median BV diameter is significantly smaller in the shell than the core based on confocal image measurements, and a similar trend occurs in iDISCO-cleared tissue. In the cleared tissue, whole BV length density and surface area density are significantly greater in the shell than the core. Finally, capillary length density is also greater in the shell than the core. The results suggest three hypotheses: First, the distinct arterial and venous systems of the rostral and caudal SCN may contribute to the in vivo variations of metabolic and neural activities observed in SCN networks. Second, the dense capillaries of the SCN shell are well positioned to transport blood-borne signals. Finally, variations in SCN vascular supply and drainage may contribute to inter-animal differences.
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影响因子：
64.8
作者：
Harris CR;Millman KJ;van der Walt SJ;Gommers R;Virtanen P;Cournapeau D;Wieser E;Taylor J;Berg S;Smith NJ;Kern R;Picus M;Hoyer S;van Kerkwijk MH;Brett M;Haldane A;Del Río JF;Wiebe M;Peterson P;Gérard-Marchant P;Sheppard K;Reddy T;Weckesser W;Abbasi H;Gohlke C;Oliphant TE
通讯作者：
Oliphant TE
影响因子：
4.2
作者：
BANKS, WA;KASTIN, AJ;MICHALS, EA
通讯作者：
MICHALS, EA
影响因子：
9.9
作者：
FRIEDLAND, RP;IADECOLA, C
通讯作者：
IADECOLA, C
周细胞变性导致神经血管解偶联并限制大脑的供氧
影响因子：
25
作者：
Kisler K;Nelson AR;Rege SV;Ramanathan A;Wang Y;Ahuja A;Lazic D;Tsai PS;Zhao Z;Zhou Y;Boas DA;Sakadžić S;Zlokovic BV
通讯作者：
Zlokovic BV
人与动物血液之间血液学变异对血管靶向载体的结合功效的影响。
影响因子：
4.6
作者：
Namdee K;Carrasco-Teja M;Fish MB;Charoenphol P;Eniola-Adefeso O
通讯作者：
Eniola-Adefeso O