Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus: an association with clinical significance.
Accessory gene regulator group polymorphisms in methicillin-resistant Staphylococcus aureus: an association with clinical significance.
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DOI：
10.3349/ymj.2007.48.2.176
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发表时间：
2007-04-30
影响因子：
2.4
通讯作者：
Song YG
中科院分区：
文献类型：
--
作者：
Yoon HJ;Choi JY;Lee K;Yong D;Kim JM;Song YG
金黄色葡萄球菌中的毒力基因表达受辅助基因调节因子 (agr) 等调节因子控制。根据agrD和agrC多态性，菌株可分为四个主要agr组（agr I-IV）。本研究的目的是确定韩国三级医疗教学医院耐甲氧西林金黄色葡萄球菌 (MRSA) 菌株 agr I、II 和 III 多态性的比例，并比较 I 组和非 I 组多态性之间的临床特征。通过 RFLP（限制性片段长度多态性）评估了总共 158 个临床分离株。患者的平均年龄为50.2±21.9岁。 agr I、II、III、I+II、I+III 组多态性分别为 74 株（49.3%）、66 株（44.0%）、10 株（6.7%）、7 株（4.4%）、1 株（0.6%）。根据单变量（p=0.001）和多变量分析（OR，4.721（1.273-17.508），p=0.020），只有耳部感染是具有统计学意义的临床参数。这项研究表明，agr I 组在韩国最为流行，耳部感染与 I 组多态性相关，这与西方国家的临床趋势不同。还可以推断社区获得性 MRSA 与 agr I 组相关。
Virulent gene expression in Staphylococcus aureus is controlled by regulators such as the accessory gene regulator (agr). Strains can be divided into four major agr groups (agr I-IV) on the basis of agrD and agrC polymorphisms. The purpose of this study was to define the proportion of agr I, II, and III polymorphisms and to compare the clinical characteristics between group I and non-group I polymorphisms of methicillin-resistant Staphylococcus aureus (MRSA) strains in a Korean tertiary care teaching hospital. A total of 158 clinical isolates were evaluated by RFLPs (restriction fragment length polymorphisms). The mean age of the patients was 50.2±21.9 years old. There were 74 (49.3%), 66 (44.0%), 10 (6.7%), 7 (4.4%), and 1 (0.6%) strains in agr group I, II, III, I+II, and I+III polymorphisms, respectively. Only ear infections were a statistically significant clinical parameter according to univariate (p=0.001) and multivariate analysis (OR, 4.721 (1.273-17.508), p=0.020). This study suggests that agr group I is the most prevalent in Korea, and ear infections are correlated with the group I polymorphism, which is a different clinical trend from western countries. It can also be inferred that community-acquired MRSA correlates with agr group I.
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影响因子：
3.1
作者：
GILLASPY, AF;HICKMON, SG;SMELTZER, MS
通讯作者：
SMELTZER, MS
影响因子：
4.9
作者：
Gomes, AR;Vinga, S;de Lencastre, H
通讯作者：
de Lencastre, H
影响因子：
15.9
作者：
CHEUNG, AL;EBERHARDT, KJ;BAYER, AS
通讯作者：
BAYER, AS
影响因子：
3.2
作者：
Jarraud, S;Lyon, GJ;Novick, RP
通讯作者：
Novick, RP
影响因子：
6.4
作者：
Goerke, C;Kümmel, M;Wolz, C
通讯作者：
Wolz, C