Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.
Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.
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DOI：
10.1016/j.jad.2021.03.071
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发表时间：
2021-05-15
影响因子：
6.6
通讯作者：
Tapert SF
中科院分区：
文献类型：
--
作者：
Meruelo AD;Brumback T;Nagel BJ;Baker FC;Brown SA;Tapert SF
Adolescents are at increased risk of developing major depressive disorder (MDD) than many other age groups. Although the neural correlates of MDD in adults have been studied prospectively, such adolescent depression studies are mainly cross-sectional. We extracted data regarding the relationship between cortical thickness and later development of adolescent MDD from a national community study that uses an accelerated longitudinal design to examine the psychological, environmental, and neural differences related to drinking and brain development. 692 subjects (age 12–21 years; 50% female) without a history of MDD were assessed with structural neuroimaging at baseline. We compared those 101 subjects who transitioned to MDD by 1-year follow-up to those who remained non-depressed over the same time period. FreeSurfer’s autosegmentation process estimated vertex-wide cortical thicknesses and its Query, Design, Estimate, Contrast (Qdec) application investigated cortical thickness between those who later developed MDD and those who remained without MDD (Monte Carlo corrected for multiple comparisons, vertex-wise cluster threshold of 1.3, p < 0.01). Those who transitioned in the next year to MDD had, at baseline, thinner cortices in the superior frontal cortex, precentral and postcentral regions, and superior temporal cortex, above and beyond effects attributable to age and sex. No cortical thickness sex differences or sex-by-depression interactions were observed. A larger sample size could improve statistical power and future investigations will be needed to confirm our results. Thinner cortices over frontal and temporal regions may be linked to enhanced vulnerability for future depression during the adolescent–young adulthood transition.
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影响因子：
3.4
作者：
Hirshfeld-Becker, Dina R.;Gabrieli, John D. E.;Chai, Xiaoqian J.
通讯作者：
Chai, Xiaoqian J.
影响因子：
17.7
作者：
Hoogman, Martine;Muetzel, Ryan;Franke, Barbara
通讯作者：
Franke, Barbara
影响因子：
5.5
作者：
Hallfors, DD;Waller, MW;Iritani, B
通讯作者：
Iritani, B
影响因子：
4.5
作者：
Freeman A;Tyrovolas S;Koyanagi A;Chatterji S;Leonardi M;Ayuso-Mateos JL;Tobiasz-Adamczyk B;Koskinen S;Rummel-Kluge C;Haro JM
通讯作者：
Haro JM
DOI：
10.1111/jcpp.12895
发表时间：
2018-09
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Bos MGN;Peters S;van de Kamp FC;Crone EA;Tamnes CK
通讯作者：
Tamnes CK