Emerging depression in adolescence coincides with accelerated frontal cortical thinning.
Emerging depression in adolescence coincides with accelerated frontal cortical thinning.
复制标题
DOI：
10.1111/jcpp.12895
复制
发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Tamnes CK
中科院分区：
文献类型：
--
作者：
Bos MGN;Peters S;van de Kamp FC;Crone EA;Tamnes CK
青春期是一个以情绪反应加剧为特征的过渡时期，这为一些人出现抑郁症状奠定了基础。先前的研究表明，青少年抑郁症与异常的皮质和皮质下大脑结构有关。然而，纵向研究目前很少，但对于检测哪些青少年有出现抑郁症状的风险至关重要。在这项纵向研究中，社区样本中的 205 名参与者接受了磁共振成像 (MRI)，每两年一次（522 次扫描），跨越 5 年，年龄介于 8 岁至 25 岁之间。在第三个时间点使用自我报告评估抑郁症状。混合模型用于检查大脑结构发育，特别是皮质厚度、表面积和皮质下体积（海马体和杏仁核）的区域变化与抑郁症状之间的关系。在第三个时间点出现抑郁症状的青少年中观察到额叶皮质加速变薄。在控制了父母在第一个时间点报告的情感问题后，这种效应仍然存在。此外，这种效应是由特定的外侧眶额和中央前区域驱动的。此外，对于报告较高抑郁症状的参与者，发现了几个区域的顶叶皮质厚度和表面积的差异发育轨迹，但这些结果未能通过多重比较的校正。海马体或杏仁核的体积或发育体积变化与抑郁症状无关。这项研究表明，新出现的抑郁症与个体额叶区域皮质变薄有关。这些发现超出了检测横截面相关性的范围，并为早期检测奠定了基础，这可能为未来的干预提供信息。
Adolescence is a transition period characterized by heightened emotional reactivity, which for some sets the stage for emerging depressive symptoms. Prior studies suggest that adolescent depression is associated with deviant cortical and subcortical brain structure. Longitudinal studies are, however, currently scarce, but critical to detect which adolescents are at risk for developing depressive symptoms. In this longitudinal study, a community sample of 205 participants underwent magnetic resonance imaging (MRI) in three biennial waves (522 scans) spanning 5 years across ages 8–25 years. Depressive symptomatology was assessed using self‐report at the third time point. Mixed models were used to examine the relations between structural brain development, specifically regional change in cortical thickness, surface area and subcortical volumes (hippocampus and amygdala), and depressive symptoms. Accelerated frontal lobe cortical thinning was observed in adolescents who developed depressive symptoms at the third time point. This effect remained after controlling for parent‐reported affective problems at the first time point. Moreover, the effect was driven by specific lateral orbitofrontal and precentral regions. In addition, differential developmental trajectories of parietal cortical thickness and surface area in several regions were found for participants reporting higher depressive symptomatology, but these results did not survive correction for multiple comparisons. Volumes or developmental volume changes in hippocampus or amygdala were not related to depressive symptoms. This study showed that emerging depression is associated with cortical thinning in frontal regions within individuals. These findings move beyond detecting cross‐sectional correlations and set the stage for early detection, which may inform future intervention.
登录
查看更多内容
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
DOI：
10.1097/chi.0b013e3181a56606
发表时间：
2009-07
影响因子：
13.3
作者：
Klein DN;Shankman SA;Lewinsohn PM;Seeley JR
通讯作者：
Seeley JR
影响因子：
26.1
作者：
Jensen, Sarah K. G.;Dickie, Erin W.;Schwartz, Deborah H.;Evans, C. John;Dumontheil, Iroise;Paus, Tomas;Barker, Edward D.
通讯作者：
Barker, Edward D.
影响因子：
4.2
作者：
Mensen, Vincent T.;Wierenga, Lara M.;van Dijk, Sarai;Rijks, Yvonne;Oranje, Bob;Mandl, Rene C. W.;Durston, Sarah
通讯作者：
Durston, Sarah
影响因子：
4.3
作者：
Klein A;Tourville J
通讯作者：
Tourville J