Lipid Droplets, Phospholipase A(2), Arachidonic Acid, and Atherosclerosis.
Lipid Droplets, Phospholipase A(2), Arachidonic Acid, and Atherosclerosis.
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脂滴、磷脂酶A(2)、花生四烯酸和动脉粥样硬化。
DOI：
10.3390/biomedicines9121891
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发表时间：
2021-12-13
期刊：
影响因子：
4.7
通讯作者：
Balsinde J
中科院分区：
文献类型：
--
作者：
Bermúdez MA;Balboa MA;Balsinde J
脂滴是一种静态的储存细胞器，目前被认为是一种动态结构，参与脂质代谢、细胞稳态和信号转导的关键过程。对动脉粥样硬化斑块炎症状态的研究表明，循环单核细胞与内皮细胞释放的产物相互作用，并可能在穿过内皮屏障并分化为巨噬细胞之前获得泡沫表型。大量释放到血流中的一种这样的化合物是花生四烯酸，花生四烯酸是类花生酸的常见前体，并且是循环单核细胞中中性脂质合成和脂滴形成的有效诱导剂。磷脂酶A2家族的成员，其水解存在于磷脂的sn-2位置的脂肪酸，最近已经成为脂滴稳态的关键控制器，调节它们的形成和脂肪酸的可用性以用于脂质介质的产生。在本文中，我们讨论了最近的研究结果有关的免疫细胞中的脂滴动力学和这些细胞器的方式参与调节花生四烯酸的可用性和代谢的背景下，动脉粥样硬化。
Lipid droplets, classically regarded as static storage organelles, are currently considered as dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and signaling. Studies on the inflammatory state of atherosclerotic plaques suggest that circulating monocytes interact with products released by endothelial cells and may acquire a foamy phenotype before crossing the endothelial barrier and differentiating into macrophages. One such compound released in significant amounts into the bloodstream is arachidonic acid, the common precursor of eicosanoids, and a potent inducer of neutral lipid synthesis and lipid droplet formation in circulating monocytes. Members of the family of phospholipase A2, which hydrolyze the fatty acid present at the sn-2 position of phospholipids, have recently emerged as key controllers of lipid droplet homeostasis, regulating their formation and the availability of fatty acids for lipid mediator production. In this paper we discuss recent findings related to lipid droplet dynamics in immune cells and the ways these organelles are involved in regulating arachidonic acid availability and metabolism in the context of atherosclerosis.
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影响因子：
6.5
作者：
Aryal P;Syed I;Lee J;Patel R;Nelson AT;Siegel D;Saghatelian A;Kahn BB
通讯作者：
Kahn BB
影响因子：
3.5
作者：
Balsinde, J;Winstead, MV;Dennis, EA
通讯作者：
Dennis, EA
影响因子：
4.8
作者：
Balboa, MA;Shirai, Y;Dennis, EA
通讯作者：
Dennis, EA
DOI：
10.1016/0005-2760(93)90010-7
发表时间：
1993-11-03
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BLANK, ML;SMITH, ZL;SNYDER, F
通讯作者：
SNYDER, F
影响因子：
4.4
作者：
Balboa, MA;Pérez, R;Balsinde, J
通讯作者：
Balsinde, J