Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection.
Analysis of human papillomavirus type 16 variants indicates establishment of persistent infection.
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对人乳头瘤病毒 16 型变种的分析表明存在持续感染。
DOI：
10.1093/infdis/172.3.747
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Galloway,DA
中科院分区：
文献类型：
--
作者：
Xi,LF;Demers,GW;Koutsky,LA;Kiviat,NB;Kuypers,J;Watts,DH;Holmes,KK;Galloway,DA
Sequence differences in the noncoding region of the human papillomavirus type 16 (HPV-16) genome were displayed using single-stranded conformational polymorphism (SSCP) analysis of polymerase chain reaction (PCR)-amplified material. Two variants accounted for 50%–70% of all HPV-16 variants from 3 cohorts in Seattle. Seventy subjects who were repeatedly HPV-16 DNA-positive over 2–8 4-monthly visits showed an identical SSCP pattern at every visit. Only 10%–20% of the specimens showed evidence of infection by multiple variants when assessed by SSCP. However, cloning and sequencing of the PCR products revealed a substantially higher proportion of specimens with > 1 variant. Sequencing many clones from each specimen confirmed that 1 major variant seemed to predominate over time, whereas minor variants appeared more transient. These results suggest that HPV-16 establishes a persistent infection in which a single variant predominates: coinfection with additional HPV-16 variants results in a minor population of HPV-16 genomes.
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临床样本中 16 型人乳头瘤病毒的序列变异允许验证和扩展流行病学研究以及构建系统发育树
影响因子：
9.4
作者：
Lip;S. Chan;Vincent T. K. Chow;T. Chong;S. Tay;Luisa L. Villa;H. Bernard
通讯作者：
H. Bernard
人乳头瘤病毒6型和16型L1和E7开放阅读框的核苷酸和氨基酸序列变异。
影响因子：
3.7
作者：
J. Icenogle;Pushpa Sathya;DonnaL. Miller;R. Tucker;William Erawls
通讯作者：
William Erawls
DOI：
10.1073/pnas.86.23.9253
发表时间：
1989-12-01
影响因子：
11.1
作者：
KEOHAVONG, P;THILLY, WG
通讯作者：
THILLY, WG
DOI：
10.1073/pnas.89.13.5799
发表时间：
1992-07-01
影响因子：
11.1
作者：
CHIANG, CM;USTAV, M;CHOW, LT
通讯作者：
CHOW, LT
HPV DNA 呈阳性的年轻女性的阴道镜和组织学检查结果以及人乳头瘤病毒 (HPV) DNA 检测变异性。
DOI：
10.1093/infdis/166.5.951
发表时间：
1992
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Moscicki,AB;Palefsky,JM;Gonzales,J;Smith,G;Schoolnik,GK
通讯作者：
Schoolnik,GK