Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial.
Prognostic significance of gamma-glutamyltransferase in patients with endometrial cancer: a multi-centre trial.
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DOI：
10.1038/bjc.2012.16
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发表时间：
2012-04-24
影响因子：
8.8
通讯作者：
Concin, N.
中科院分区：
文献类型：
--
作者：
Seebacher, V.;Polterauer, S.;Grimm, C.;Rahhal, J.;Hofstetter, G.;Bauer, E-M;Husslein, H.;Leipold, H.;Marth, C.;Reinthaller, A.;Concin, N.
关键词：
γ-谷氨酰转移酶（GTT）是一种已知的凋亡平衡标志物，似乎可以促进肿瘤进展、侵袭和耐药性。最近，高GGT血清水平被证明与宫颈癌患者预后受损相关。本研究的目的是探讨治疗前血清GGT水平作为子宫内膜癌患者预后参数的价值。在本多中心试验中，对874例连续子宫内膜癌患者的临床病理参数和治疗前血清GGT水平进行了评价。患者按GGT危险组分层，并进行单变量和多变量生存分析。平均治疗前血清GGT水平为30.8（41.5）U l-1。在单变量和多变量生存分析中，血清GGT水平升高和高度升高（P=0.03和P=0.005）、肿瘤分期（P <0.001和P<0.001）、分级（P<0.001和P=0.02）和年龄（P<0.001和P<0.001）与无进展生存独立相关。治疗前GGT与晚期肿瘤分期（P=0.6）、较高的组织学分级（P=0.6）或不利的组织学亚型（P=0.3）无关。治疗前血清GGT是子宫内膜癌患者无进展生存期的一个新的独立预后参数。将患者分为预后亚组可用于患者咨询和个性化治疗计划。
Gamma-glutamyltransferase (GTT), a known marker for apoptotic balance, seems to promote tumour progression, invasion and drug resistance. Recently, high GGT serum levels were shown to be associated with impaired prognosis in patients with cervical cancer. The aim of this study was to investigate the value of pre-therapeutic serum GGT levels as prognostic parameter in patients with endometrial cancer. Within the present multi-centre trial, clinical–pathological parameters and pre-therapeutic serum GGT levels were evaluated in 874 consecutive patients with endometrial cancer. Patients were stratified in GGT risk groups, and univariate and multivariable survival analyses were performed. Mean pre-therapeutic serum GGT level was 30.8 (41.5) U l–1. Elevated and highly elevated serum GGT levels (P=0.03 and P=0.005), tumour stage (P<0.001 and P<0.001), grade (P<0.001 and P=0.02) and age (P<0.001 and P<0.001) were independently associated with progression-free survival in univariate and multivariable survival analyses. Pre-therapeutic GGT was not associated with advanced tumour stage (P=0.6), higher histological grade (P=0.6) or unfavourable histological subtype (P=0.3). Pre-therapeutic serum GGT is a novel and independent prognostic parameter for progression-free survival of patients with endometrial cancer. Stratifying patients into prognostic subgroups could be used for patient counselling and individualised treatment planning.
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