Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG.
Large-Scale Desynchronization During Interictal Epileptic Discharges Recorded With Intracranial EEG.
复制标题
DOI：
10.3389/fneur.2020.529460
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Nguyen DK
中科院分区：
文献类型：
--
作者：
Bou Assi E;Zerouali Y;Robert M;Lesage F;Pouliot P;Nguyen DK
人们越来越认识到，深入了解癫痫发作需要定位和表征癫痫发作区域的功能网络，即癫痫发作区域的功能网络。 e. 癫痫病灶。先前对致痫灶功能连接的研究得出了相反的结果，报告了在休息期间和癫痫发作期间病理性的增加和减少。在这项研究中，我们改变了范式来研究与发作间期癫痫样放电相关的连接的时间过程。我们招募了 35 名癫痫患者，接受颅内脑电图 (iEEG) 检查，作为术前评估的一部分。对于每位患者，标记了 50 次发作间期癫痫放电 (IED)，并在这些标记周围记录了 iEEG 信号。对信号进行窄带滤波，并计算时间分辨锁相值，以跟踪 IED 期间功能连接的动态。结果表明，IED 与全局功能连接的瞬时下降有关，时间锁定到放电峰值，并且特定于伽马频带的高范围。癫痫病灶和其他大脑区域之间的远程连接的破坏可能是癫痫活动产生的重要过程。短暂的去同步化可能是致痫灶的一个潜在生物标志物，因为1）涉及病灶的功能连接比病灶外的连接下降显着更多，2）手术结果良好的患者似乎比预后不良的患者有更多的失联病灶。
It is increasingly recognized that deep understanding of epileptic seizures requires both localizing and characterizing the functional network of the region where they are initiated, i. e., the epileptic focus. Previous investigations of the epileptogenic focus' functional connectivity have yielded contrasting results, reporting both pathological increases and decreases during resting periods and seizures. In this study, we shifted paradigm to investigate the time course of connectivity in relation to interictal epileptiform discharges. We recruited 35 epileptic patients undergoing intracranial EEG (iEEG) investigation as part of their presurgical evaluation. For each patient, 50 interictal epileptic discharges (IEDs) were marked and iEEG signals were epoched around those markers. Signals were narrow-band filtered and time resolved phase-locking values were computed to track the dynamics of functional connectivity during IEDs. Results show that IEDs are associated with a transient decrease in global functional connectivity, time-locked to the peak of the discharge and specific to the high range of the gamma frequency band. Disruption of the long-range connectivity between the epileptic focus and other brain areas might be an important process for the generation of epileptic activity. Transient desynchronization could be a potential biomarker of the epileptogenic focus since 1) the functional connectivity involving the focus decreases significantly more than the connectivity outside the focus and 2) patients with good surgical outcome appear to have a significantly more disconnected focus than patients with bad outcomes.
登录
查看更多内容
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
5.6
作者：
Hufnagel, A;Dümpelmann, M;Elger, CE
通讯作者：
Elger, CE
影响因子：
2.7
作者：
Jmail, Nawel;Gavaret, Martine;Benar, Christian-G.
通讯作者：
Benar, Christian-G.
影响因子：
3.5
作者：
Kaplan, Raphael;Bush, Daniel;Bonnefond, Mathilde;Bandettini, Peter A.;Barnes, Gareth R.;Doeller, Christian F.;Burgess, Neil
通讯作者：
Burgess, Neil
影响因子：
2.2
作者：
Assi, Elie Bou;Rihana, Sandy;Sawan, Mohamad
通讯作者：
Sawan, Mohamad