Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure.

Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure.
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自然发生慢性肾衰竭的狗淋巴细胞功能和亚群的变化。

DOI:
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发表时间:
2010
期刊:
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
影响因子:
--
通讯作者:
M. Toman
M. Toman
中科院分区:
--
文献类型:
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作者:
S. Králová;L. Levá;M. Toman

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慢性肾功能衰竭(CRF)引起人类免疫抑制,被认为是犬非感染性继发性免疫抑制的原因之一。对CRF各阶段犬的血液样本进行血液学、生化和免疫学检查。淋巴细胞减少症犬的数量随着临床体征的进展而增加。淋巴细胞的所有主要亚群均减少,但在B细胞、Tc细胞和NK细胞中检测到更显著的减少。抑制淋巴细胞反应伴刀豆球蛋白A和美洲商陆丝裂原被发现在狗严重的临床症状和淋巴细胞减少症。我们的结果显示免疫功能受损,与尿毒症患者的结果相似,表明感染可能是CRF犬的重要并发症。
Chronic renal failure (CRF) causes immunosuppresion in humans and is thought to be one of the causes of noninfectious secondary immunosuppression in dogs. Hematological, biochemical, and immunological examinations were performed on blood samples obtained from dogs in various stages of CRF. The number of dogs with lymphopenia increased with the progression of clinical signs. All main subsets of lymphocytes were decreased, but more considerable reduction was detected in B-cells, Tc-cells, and NK cells. Depressed lymphocyte response to concanavalin A and pokeweed mitogen was found in dogs with severe clinical signs and lymphopenia. Our results, showing impaired immunological functions, are similar to results obtained from uremic humans, suggesting that infection may be an important complication in dogs with CRF.
甲状旁腺激素的测定及其在终末期肾病患者中的应用。
DOI: 10.1159/000067857
发表时间: 2003
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影响因子: --
作者:
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