Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure.
Changes in lymphocyte function and subsets in dogs with naturally occurring chronic renal failure.
复制标题
自然发生慢性肾衰竭的狗淋巴细胞功能和亚群的变化。
DOI:
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发表时间:
2010
期刊:
影响因子:
--
通讯作者:
M. Toman
中科院分区:
文献类型:
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作者:
S. Králová;L. Levá;M. Toman
Chronic renal failure (CRF) causes immunosuppresion in humans and is thought to be one of the causes of noninfectious secondary immunosuppression in dogs. Hematological, biochemical, and immunological examinations were performed on blood samples obtained from dogs in various stages of CRF. The number of dogs with lymphopenia increased with the progression of clinical signs. All main subsets of lymphocytes were decreased, but more considerable reduction was detected in B-cells, Tc-cells, and NK cells. Depressed lymphocyte response to concanavalin A and pokeweed mitogen was found in dogs with severe clinical signs and lymphopenia. Our results, showing impaired immunological functions, are similar to results obtained from uremic humans, suggesting that infection may be an important complication in dogs with CRF.
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影响因子:
3
作者:
Goodman,WilliamG
通讯作者:
Goodman,WilliamG
影响因子:
19.6
作者:
Jaber, BL;Cendoroglo, M;Pereira, BJG
通讯作者:
Pereira, BJG
DOI:
--
发表时间:
1986
期刊:
Journal of experimental pathology
影响因子:
--
作者:
Raskova,J;Czerwinski,DK;Shea,SM;RaskaJr,K
通讯作者:
RaskaJr,K
影响因子:
2.5
作者:
Stojceva-Taneva,O;Fadda,GZ;Smogorzewski,M;Massry,SG
通讯作者:
Massry,SG