Doppler optical coherence tomography in cardiovascular physiology
Doppler optical coherence tomography in cardiovascular physiology
复制标题
多普勒光学相干断层扫描在心血管生理学中的应用
DOI：
10.1117/12.822553
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Bonesi M
中科院分区：
文献类型：
--
作者：
Bonesi M
复杂几何形状血管中的流动动力学研究在许多生物医学应用中非常重要，其中移动流体和外壳介质之间的机械相互作用的知识对于确定感兴趣的参数起着关键作用，包括血流对动脉粥样硬化斑块可能破裂的影响。多普勒光学相干断层扫描（DOCT）作为光学相干断层扫描（OCT）的功能扩展，是一种光学、非接触、非侵入性技术，能够实现对血流/血管相互作用的详细分析。它可以同时对容器的形态和成分进行高分辨率成像（典型为 10μm），并确定沿测量横截面的流速分布。我们应用 DOCT 系统对在复杂几何形状的血管中流动的牛顿和非牛顿流体的高分辨率一维和多维速度分布轮廓进行成像，包括 Y 形和 T 形血管、动脉瘤血管、部署支架和支架的分叉血管。该模型旨在模仿人体血管的典型形状，从而能够初步分析流动动力学与血管（复杂）几何形状之间的相互作用，并绘制多个入口体积流量下的相关速度分布图。讨论了定量观察复杂几何容器内产生的流动湍流的可行性研究。此外，DOCT技术还应用于小鼠体内脑血流监测。呈现了血管模型中复杂流速分布和体内小鼠颅下血流速度分布的二维 DOCT 图像。
The study of flow dynamics in complex geometry vessels is highly important in many biomedical applications where the knowledge of the mechanic interactions between the moving fluid and the housing media plays a key role for the determination of the parameters of interest, including the effect of blood flow on the possible rupture of atherosclerotic plaques. Doppler Optical Coherence Tomography (DOCT), as a functional extension of Optical Coherence Tomography (OCT), is an optic, non-contact, non-invasive technique able to achieve detailed analysis of the flow/vessel interactions. It allows simultaneous high resolution imaging (10μmtypical) of the morphology and composition of the vessel and determination of the flow velocity distribution along the measured cross-section. We applied DOCT system to image high-resolution one-dimensional and multi-dimensional velocity distribution profiles of Newtonian and non-Newtonian fluids flowing in vessels with complex geometry, including Y-shaped and T-shaped vessels, vessels with aneurism, bifurcated vessels with deployed stent and scaffolds. The phantoms were built to mimic typical shapes of human blood vessels, enabling preliminary analysis of the interaction between flow dynamics and the (complex) geometry of the vessels and also to map the related velocity profiles at several inlet volume flow rates. Feasibility studies for quantitative observation of the turbulence of flows arising within the complex geometry vessels are discussed. In addition, DOCT technique was also applied for monitoring cerebral mouse blood flow in vivo. Two-dimensional DOCT images of complex flow velocity profiles in blood vessel phantoms and in vivo sub-cranial mouse blood flow velocities distributions are presented.
登录
查看更多内容
基于实时数字信号处理的光学相干断层扫描和多普勒光学相干断层扫描
影响因子：
4.6
作者：
A. W. Schaefer;J. J. Reynolds;D. Marks;S. Boppart
通讯作者：
S. Boppart
影响因子：
3.6
作者：
Everett, MJ;Schoenenberger, K;Da Silva, LB
通讯作者：
Da Silva, LB
影响因子：
3.5
作者：
A. Rollins;S. Yazdanfar;J. Barton;J. Izatt
通讯作者：
A. Rollins;S. Yazdanfar;J. Barton;J. Izatt
影响因子：
3.5
作者：
Z. Yaqoob;Jigang Wu;Emily J. McDowell;Xin Heng;Changhuei Yang
通讯作者：
Z. Yaqoob;Jigang Wu;Emily J. McDowell;Xin Heng;Changhuei Yang
血管内光学相干断层扫描——打开了解冠状动脉疾病的窗口
DOI：
--
发表时间：
2005
期刊：
影响因子：
--
作者：
J. Schmitt;David Kolstad;C. Petersen
通讯作者：
C. Petersen