Genome profiling of mismatch repair genes in eight types of tumors
Genome profiling of mismatch repair genes in eight types of tumors
复制标题
八种肿瘤错配修复基因的基因组分析
DOI：
10.1080/15384101.2021.1922160
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发表时间：
2021-05
期刊：
影响因子：
4.3
通讯作者：
Zhu Chen
中科院分区：
文献类型：
--
作者：
Wang Siqi;Guan Gefei;Zou Cunyi;Guo Qing;Cheng Wen;Shen Shuai;Dong Fang;Wu Anhua;Li Guang;Zhu Chen
ABSTRACT Mismatch repair (MMR) plays an important role in the occurrence and development of tumors. At present, it is widely believed that MMR is a protective mechanism of tumors that plays a critical role in the progresses of cancer. In this study, 34 genes related to MMR selected from Gene Ontology (GO) database were scored by single sample Gene sets enrichment analysis (ssGSEA), and eight cancers were screened from 23 TCGA solid cancers to investigate the clinical significance of MMR score. MMR had different effects on the prognosis of the eight tumors, with a protective effect in three cancers and functioning as a risk factor in the remaining five cancers. We used unsupervised clustering to divide the patients into four clusters. We found that the immune and metabolic status of the four clusters were extremely different, among which cluster1 had the lowest tumor purity and the most complex microenvironment; this may explain its poor prognosis and immunotherapy effect. In summary, MMR scores can improve the predictive ability and provide effective guidance for immunotherapy in individual type of tumors.
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影响因子：
2.6
作者：
Kim E;Zschiedrich S
通讯作者：
Zschiedrich S
DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
64.5
作者：
Haldar M;Kohyama M;So AY;Kc W;Wu X;Briseño CG;Satpathy AT;Kretzer NM;Arase H;Rajasekaran NS;Wang L;Egawa T;Igarashi K;Baltimore D;Murphy TL;Murphy KM
通讯作者：
Murphy KM
影响因子：
4.7
作者：
Xu WX;Zhang J;Hua YT;Yang SJ;Wang DD;Tang JH
通讯作者：
Tang JH
影响因子：
3.9
作者：
Kato M;Takano M;Miyamoto M;Sasaki N;Goto T;Tsuda H;Furuya K
通讯作者：
Furuya K