Clinical characteristics and immunogenetics of BCGosis/BCGitis in Chinese children: a 6 year follow-up study.
Clinical characteristics and immunogenetics of BCGosis/BCGitis in Chinese children: a 6 year follow-up study.
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中国儿童卡介苗病/卡介苗炎的临床特征和免疫遗传学：一项 6 年随访研究。
DOI：
10.1371/journal.pone.0094485
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Ying W;Sun J;Liu D;Hui X;Yu Y;Wang J;Wang X
在本研究中，对中国卡介苗病/卡介苗炎患者的临床和免疫遗传学特征进行了调查。对于免疫功能异常的患者，采用Sanger测序来鉴定相关基因。 2007 年至 2012 年期间，确诊了 74 例卡介苗病/卡介苗炎病例。按感染组织器官分类，单纯局部感染无一例，区域感染39例，远处感染21例，播散性感染14例。 32 名患者 (43.2%) 患有明确的原发性免疫缺陷病 (PID)，慢性肉芽肿病 (CGD) 是最常见的 PID（n = 23，占所有 PID 患者的 71.9%）。对于CGD患者，在抗结核治疗的基础上，给予rhIFN-γ可以更好地控制卡介苗病/卡介苗炎。结果表明，PID 与 BCG 疾病的易感性相关。对于卡介苗病/卡介苗炎患儿，免疫功能评估是必要的，IFN-γ治疗对伴有CGD的卡介苗病/卡介苗炎患者有效。
In this study, the clinical and immunogenetical features in a cohort of Chinese patients with BCGosis/BCGitis were investigated. For the patients with abnormal immunological functions, Sanger sequencing was used to identify the involved genes. There were 74 confirmed cases of BCGosis/BCGitis during 2007–2012. Classified by infected tissues and organs, no cases only had local infection, 39 patients had a regional infection, 21 patients had a distant infection and 14 patients had a disseminated infection. Thirty-two patients (43.2%) had definitive primary immunodeficiency diseases (PID) and chronic granulomatous disease (CGD) is the most common PID (n = 23, accounted for 71.9% of all PID patients). For CGD patients, based on the anti-tuberculosis treatment, administration of rhIFN-γ resulted in better control of BCGosis/BCGitis. The results indicate that PIDs are associated with susceptibility to BCG disease. For children with BCGosis/BCGitis, immune function evaluation is necessary, and IFN-γ treatment for BCGosis/BCGitis patients with CGD is effective.
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1.4
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