Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in Zucker diabetic fatty rats.
Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in Zucker diabetic fatty rats.
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经皮耳迷走神经刺激触发褪黑激素分泌并在 Zucker 糖尿病肥胖大鼠中具有抗抑郁作用
DOI：
10.1371/journal.pone.0111100
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Li S;Zhai X;Rong P;McCabe MF;Zhao J;Ben H;Wang X;Wang S
循环中的褪黑素减少与抑郁症有关。我们最近发现，Zucker糖尿病肥胖大鼠(ZDF，fa/fa)表现出抑郁样行为，经皮耳迷走神经刺激(TaVNS)对ZDF大鼠具有抗抑郁作用。在此，我们研究了ZDF大鼠是否可以作为抑郁症啮齿动物模型，以及taVNS的抗抑郁作用是否通过调节褪黑素的分泌来实现。使用成年雄性ZDF和Zucker瘦肉型(ZL，FA/+)窝产仔。松果体完整组(n = 8)、ZL组(n = 6)和去松果体大鼠(n = 8)在麻醉状态下每天进行30min-TAVNS(2/15 Hz，2 mA)，连续34d。第35天用强迫游泳试验(FST)判断抑郁行为，用酶联免疫吸附试验(ELISA)检测血浆褪黑素浓度。我们发现，幼稚的ZDF大鼠在FST中有更长的不动时间，长期(34天)的taVNS治疗改善了抑郁样行为。在松果体完整和松果体切除的ZDF大鼠中，taVNS在taVNS过程中和之后都诱导了急性褪黑素的分泌。ZDF大鼠(R = −0.544)与ZL大鼠(R = 0.247)相比，褪黑素水平低与FST表现差有关。综上所述，我们的结果表明，ZDF大鼠是先天抑郁的理想候选者，而taVNS通过刺激褪黑激素的分泌和增加其产生来抗抑郁。
Decreased circulating melatonin is implicated in depression. We recently found that Zucker diabetic fatty rats (ZDF, fa/fa) develop depression-like behaviors and that transcutaneous auricular vagus nerve stimulation (taVNS) is antidepressive in ZDF rats. Here we studied whether the ZDF rats could be used as a depression rodent model and whether the antidepressive effect of taVNS is mediated through modulation of melatonin secretion. Adult male ZDF and Zucker lean (ZL, fa/+) littermates were used. 30 min-taVNS procedures (2/15 Hz, 2 mA) were administered once daily under anesthesia for 34 consecutive days in pineal intact ZDF (n = 8) and ZL (n = 6) rats, as well as in pinealectomized ZDF rats (n = 8). Forced swimming test (FST) was used to determine depression-like behavior and ELISA to detect plasma melatonin concentration on day 35. We found that naïve ZDF rats had a longer immobility time in FST and that long-term (34 days) taVNS treatment ameliorated the depression-like behavior. In both pineal intact and pinealectomized ZDF rats, taVNS induced acute melatonin secretion, both during and after the taVNS session. A low melatonin level is related to the poor FST performance in ZDF rats (R = −0.544) in contrast to ZL rats (R = 0.247). In conclusion, our results show that ZDF rats are ideal candidates of innate depression and that taVNS is antidepressive through triggering melatonin secretion and increasing its production.
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DOI：
10.1161/hypertensionaha.110.160671
发表时间：
2011-03
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Ward KR;Bardgett JF;Wolfgang L;Stocker SD
通讯作者：
Stocker SD
影响因子：
0.3
作者：
Chao, DM;Chen, G;Cheng, JS
通讯作者：
Cheng, JS
前脑谷氨酸能神经元介导瘦素对抑郁样行为和突触抑郁症的作用。
影响因子：
6.8
作者：
Guo M;Lu Y;Garza JC;Li Y;Chua SC;Zhang W;Lu B;Lu XY
通讯作者：
Lu XY
影响因子：
2.9
作者：
Wang S;Zhang L;Lim G;Sung B;Tian Y;Chou CW;Hernstadt H;Rusanescu G;Ma Y;Mao J
通讯作者：
Mao J
影响因子：
--
作者：
Huang F;Dong J;Kong J;Wang H;Meng H;Spaeth RB;Camhi S;Liao X;Li X;Zhai X;Li S;Zhu B;Rong P
通讯作者：
Rong P