The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations.
The effect of glucose-dependent insulinotropic polypeptide (GIP) variants on visceral fat accumulation in Han Chinese populations.
复制标题
葡萄糖依赖性促胰岛素多肽（GIP）变异体对中国汉族人群内脏脂肪积累的影响
DOI：
10.1038/nutd.2017.28
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发表时间：
2017-05-22
影响因子：
6.1
通讯作者：
Hu C
中科院分区：
文献类型：
--
作者：
Wang T;Ma X;Tang T;Higuchi K;Peng D;Zhang R;Chen M;Yan J;Wang S;Yan D;He Z;Jiang F;Bao Y;Jia W;Ishida K;Hu C
目的：探讨葡萄糖依赖性促胰岛素多肽（GIP）对中国汉族人群脂肪分布和糖代谢的影响。方法：对2884名中国汉族人群中GIP的6个标签单核苷酸多态性（SNP）和葡萄糖依赖性促胰岛素多肽受体（GIPR）的4个标签SNP进行基因分型。线性分析被施加到测试这些变量的关联与内脏脂肪面积（VFA）和皮下脂肪面积（SFA）量化的磁共振成像以及葡萄糖相关的traits.Results：我们发现，C等位基因的GIP的rs 4794008倾向于增加VFA和VFA/SFA的比例在所有科目（P= 0.050和P= 0.054，分别），和rs 4794008与VFA/SFA的比例在男性（P= 0.041）调整后的BMI。rs 4794008的VFA增加等位基因与任何葡萄糖代谢性状无关。然而，GIP基因rs 9904288与男性SFA以及所有受试者的葡萄糖相关性状相关（P范围，0.004-0.049），并且GIPR变异体显示与脂肪和葡萄糖相关性状均相关。
Objectives:We aim to validate the effects of glucose-dependent insulinotropic polypeptide (GIP) on fat distribution and glucose metabolism in Han Chinese populations.Methods:We genotyped six tag single-nucleotide polymorphisms (SNPs) of GIP and four tag SNPs of glucose-dependent insulinotropic polypeptide receptor (GIPR) among 2884 community-based individuals from Han Chinese populations. Linear analysis was applied to test the associations of these variants with visceral fat area (VFA) and subcutaneous fat area (SFA) quantified by magnetic resonance imaging as well as glucose-related traits.Results:We found that the C allele of rs4794008 of GIP tended to increase the VFA and the VFA/SFA ratio in all subjects (P= 0.050 and P= 0.054, respectively), and rs4794008 was associated with the VFA/SFA ratio in males (P= 0.041) after adjusting for the BMI. The VFA-increasing allele of rs4794008 was not related to any glucose metabolism traits. However, rs9904288 of GIP was associated with the SFA in males as well as glucose-related traits in all subjects (P range, 0.004–0.049), and the GIPR variants displayed associations with both fat-and glucose-related traits.Conclusions:The results could provide the evidence that GIP might modulate visceral fat accumulation via incretin function or independent of incretin.
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影响因子：
30.8
作者：
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影响因子：
4.9
作者：
Asmar, M.;Simonsen, L.;Bulow, J.
通讯作者：
Bulow, J.
影响因子：
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作者：
Asmar M;Simonsen L;Madsbad S;Stallknecht B;Holst JJ;Bülow J
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作者：
Sauber, Jeannine;Grothe, Jessica;Biebermann, Heike
通讯作者：
Biebermann, Heike
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4.8
作者：
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通讯作者：
McIntosh, Christopher H. S.