Myocardial kinetics of Tc-MIBI in canine myocardium after dipyridamole.
Myocardial kinetics of Tc-MIBI in canine myocardium after dipyridamole.
复制标题
双嘧达莫后犬心肌中 Tc-MIBI 的心肌动力学。
作者：
D. Glover;Robert D. Okada
氚-甲氧基异丁基异丁基异腈(99m-hexakis-2-methoxy-2-methylpropyl-isonitrile)是一种很有前途的新型心肌灌注显像剂。然而，需要使用运动或潘生丁进行成像，以检测缺血，并将挽救的但仍处于缺血状态的心肌与瘢痕区分开来。相应地，12只犬造成轻到中度的左回旋支冠状动脉狭窄(组2)，10只犬造成严重的冠状动脉回旋支狭窄(组3)。5只对照犬(第1组)无狭窄。静脉滴注潘生丁(0.08 mg/kg/min，4min)后，右心房内注射TC-MIBI。在接下来的4小时研究期间，使用微型碲化镉辐射探测器连续监测左前降支(LAD)(正常)和左回旋支(LCx)(缺血)冠状动脉(缺血)区的心肌TC-MIBI活性，并在必要时采集系列伽马相机图像。TC-MIBI迅速被非缺血、轻、中、重度缺血心肌摄取。当心肌局部血流量达到2.0ml/min/g时，心肌初始摄取与心肌局部血流量呈线性相关(r=0.97)。首次摄取后，对照组(0.09+/-0.03[+/-SEM])与第2组(0.07+/-0.03)和第3组(0.09+/-0.03)缺血区的平均4h心肌清除分数相似。TC-MIBI的血液清除是快速和双指数的，首先是快速清除阶段，然后是缓慢清除阶段。
Technetium 99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-MIBI) is a promising new myocardial perfusion imaging agent producing excellent rest images. Imaging, however, will need to be performed with exercise or dipyridamole to detect ischemia and to differentiate salvaged but still ischemic myocardium from scar. Accordingly, 12 dogs were given mild-to-moderate left circumflex coronary stenoses (group 2), and 10 dogs were given severe stenoses (group 3). In five control dogs (group 1), there was no stenosis. After an intravenous infusion of dipyridamole (0.08 mg/kg/min for 4 minutes), Tc-MIBI was injected into the right atrium. Over the next 4-hour study period, myocardial Tc-MIBI activities were continuously monitored in both the left anterior descending (LAD) (normal) and left circumflex (LCx) (ischemic) coronary artery (ischemic) zones using miniature cadmium telluride radiation detectors and serial gamma camera images were acquired when necessary. Tc-MIBI was rapidly taken up by nonischemic, mild-to-moderate, and severe ischemic myocardium. The initial myocardial uptake of Tc-MIBI was linearly related (r = 0.97) to regional myocardial blood flow at rates up to 2.0 ml/min/g. After the initial uptake, the mean 4-hour fractional myocardial clearance was similar between the control (0.09 +/- 0.03 [+/- SEM]) and group 2 (0.07 +/- 0.03) and group 3 (0.09 +/- 0.03) ischemic zones. Tc-MIBI blood clearance was rapid and biexponential with an initial fast clearance phase followed by a slow clearance phase.(ABSTRACT TRUNCATED AT 250 WORDS)
使用微型辐射探测器进行狗的局部心肌放射性示踪动力学。
DOI：
10.1152/ajpheart.1982.242.5.h849
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Jacobs,ML;Okada,RD;Daggett,WM;Fowler,BN;Strauss,HW;Geffin,G;Pohost,GM
通讯作者：
Pohost,GM