Lymphomatoid papulosis. A cutaneous proliferation of activated helper T cells expressing Hodgkin's disease-associated antigens.
Lymphomatoid papulosis. A cutaneous proliferation of activated helper T cells expressing Hodgkin's disease-associated antigens.
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淋巴瘤样丘疹病。
DOI：
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发表时间：
1985
影响因子：
6
通讯作者：
E. Vonderheid
中科院分区：
文献类型：
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作者：
M. Kadin;K. Nasu;D. Sako;J. Said;E. Vonderheid
本文报道9例淋巴瘤样丘疹病（LP）皮损中特征性大异型细胞的免疫表型。霍奇金病（HD）相关抗原Ki-1（通常为Leu-M1）与辅助性T细胞抗原T11、T4和T3以及细胞活化抗原Tac、Ia和T9的共表达是最常见的表型，在9例病例中观察到6例。2例未检测到T细胞特异性抗原，其表型与HD的Reed-Sternberg（RS）细胞无法区分。LP病例中大量Ki-1阳性细胞和罕见的大型非典型细胞表达Leu-1抗原有助于LP和蕈样肉芽肿的鉴别诊断。免疫电子显微镜显示了仅表达T细胞抗原的小，中，大细胞和表达T细胞和HD相关抗原的大转化RS样细胞之间可能的过渡。这些免疫学结果对LP的诊断是有用的，并可能有助于解释LP、蕈样肉芽肿和HD的意外频繁的临床相关性。
A distinctive immunologic phenotype was demonstrated for the characteristic large atypical cells in skin lesions of 9 patients with lymphomatoid papulosis (LP). Coexpression of Hodgkin's disease (HD)-associated antigen(s) Ki-1, and often Leu-M1, with helper T-cell antigens T11, T4, and T3 and cellular activation antigens Tac, Ia, and T9 was the most common phenotype, observed in 6 of 9 cases. In 2 cases T-cell-specific antigens were not detected, and the phenotype was indistinguishable from Reed-Sternberg (RS) cells of HD. Numerous Ki-1 positive cells and infrequent expression of Leu-1 antigen by large atypical cells in LP cases facilitated the differential diagnosis between LP and mycosis fungoides. A possible transition between small, medium, and large cells expressing only T-cell antigens and large transformed RS-like cells expressing both T-cell and HD-associated antigens was shown by immunoelectron microscopy. These immunologic findings should prove useful for the diagnosis of LP and may help to explain the unexpectedly frequent clinical associations of LP, mycosis fungoides, and HD.
DOI：
10.1073/pnas.78.5.3039
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
TROWBRIDGE, IS;OMARY, MB
通讯作者：
OMARY, MB