Childhood-Onset Adult Growth Hormone Deficiency: Clinical, Hormonal, and Radiological Assessment in a Single Center in China
Childhood-Onset Adult Growth Hormone Deficiency: Clinical, Hormonal, and Radiological Assessment in a Single Center in China
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儿童期成人生长激素缺乏症：中国单一中心的临床、激素和放射学评估
DOI：
10.1159/000478527
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Pan H
中科院分区：
文献类型：
--
作者：
Yang H;Zhu H;Yan K;Pan H
背景资料：尽管生长激素缺乏症（GHD）是儿科患者的一个重要问题，但成人GHD（AGHD）在中国是一个被忽视的内分泌学领域。本研究的目的是在中国的一个中心描述儿童期发病AGHD（CO AGHD）的临床、激素和放射学特征，并与日本的同行进行比较。研究方法：对78例中国CO AGHD患者的病历进行了审查，并与日本HypoCCS数据库研究的数据（N = 69）进行了比较。结果如下：我们的大多数患者有垂体柄中断，而下丘脑-垂体瘤是日本CO AGHD最常见的原因。中国患者的诊断滞后6年。两组中的大多数都有多种垂体激素缺乏症。两个患者组的体重指数和血脂特征相似。血脂异常和高尿酸血症是中国患者最常见的代谢紊乱。结论：我们的研究结果证实，亚洲不同国家的CO AGHD患者在病因、代谢特征和激素状态方面可能存在区域差异。
Background: Although growth hormone deficiency (GHD) is an important issue in pediatric patients, adult GHD (AGHD) is a neglected field of endocrinology in China. The aim of this study is to characterize the clinical, hormonal, and radiological features in childhood-onset AGHD (CO AGHD) in a single center in China and to compare them with counterparts from Japan. Methods: The medical records of 78 Chinese patients with CO AGHD were reviewed and compared with data from the HypoCCS database study from Japan (N = 69). Results: The majority of our patients had pituitary stalk interruption, while hypothalamo-pituitary tumors were the most common cause of CO AGHD in Japan. Chinese patients had a lag of 6 years for diagnosis. The majority of both groups had multiple pituitary hormone deficiencies. Body mass index and lipid profiles were similar between the 2 patient groups. Dyslipidemia and hyperuricemia were the most common metabolic disturbances in Chinese patients. Conclusions: Our findings confirm that there are possible regional differences in the etiology, metabolic characteristics, and hormonal status in CO AGHD patients in different countries in Asia.
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DOI：
10.1055/s-0034-1390460
发表时间：
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期刊：
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影响因子：
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DOI：
10.1016/s1001-9294(16)30046-3
发表时间：
2016-09
期刊：
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
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DOI：
10.1186/s13633-016-0024-8
发表时间：
2016
期刊：
International journal of pediatric endocrinology
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