Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
复制标题
Fast MYH 位点锁定快速肌纤维末端表型的六种同源蛋白和 linc-RNA
作者：
Iori Sakakibara;Marc Santolini;A. Ferry;V. Hakim;P. Maire
摘要哺乳动物基因组编码数千个长的基因间非编码RNA（lincRNA）。然而，这些lincRNA中的大多数的功能尚未在体内鉴定。在这里，我们证明了一种新的lincRNA，linc-MYH，在成人快速型肌纤维专业化的作用。快肌球蛋白重链（MYH）基因和linc-MYH有一个共同的增强子，位于快肌球蛋白重链（MYH）基因座上，并受Six 1同源蛋白调节。快型肌纤维核中的linc-MYH阻止慢型并增强快型基因表达。功能性快速肌节单元形成是通过快速MYH和linc-MYH的协调表达在共同的Six结合增强子的控制下实现的。
Abstract Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.
影响因子：
16.6
作者：
Rinn JL;Chang HY
通讯作者：
Chang HY