Interlocked and Knotted Rings in Biology and Chemistry
Interlocked and Knotted Rings in Biology and Chemistry
复制标题
生物学和化学中的互锁环和打结环
DOI：
--
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
J. Sauvage
中科院分区：
文献类型：
--
作者：
C. Dietrich;J. Sauvage
链烯是由两个或多个互锁环组成的化学实体。这类体系与打结分子一样，属于化学的一个分支，与数学、分子生物学和图形艺术有关。统计方法的准备，虽然很容易设想和尝试，是很少的实际效用。使用有机合成的经典反应的定向策略，提供了一个有趣的替代路线来制备互锁环系统。最新的方法，利用模板反应，无论是在过渡金属或有机电子给体或受体对肯定是最有效的索烃。例如，使用过渡金属模板方法已经实现了[3]-索烃（两个外围环分别与中心环互锁）的克级制备。金属能够聚集和预定向要并入靶分子中的若干片段。虽然DNA的打结形式相对常见，但直到最近才获得合成的分子结。这里，合成方法的成功再次依赖于使用过渡金属作为模板物质。多核双链螺旋是一种有趣的中间体化合物，可以用来制备拓扑结构复杂的分子结和索烃。第一个分子三叶结直到最近才被合成和充分表征，尽管关于化学结的理论讨论在30多年前就已经发表了。
Catenanes are chemical entities consisting of two or more interlocked rings. Such systems, as well as knotted molecules, belong to a branch of chemistry which is related to mathematics, molecular biology and graphic art. Many endeavours have been made to build such topologicaly novel compounds. The statistical methods of preparation, although very simple to conceive and to attempt, are of little practical utility. The directed strategy, using the classical reactions of organic synthesis, offers an interesting alternative route to prepare interlocked ring systems. The most recent approaches, utilizing templated reactions either on transition metals or on organic electron donoracceptor pairs are certainly the most efficient ones for making catenanes. For instance, a gram-scale preparation of [3]-catenanes (two peripheral rings separately interlocked to a central cycle) has been achieved using the transition metal template approach. The metal is able to gather and pre-oriente the several fragments to be incorporated into the target molecule. Although knotted forms of DNA are relatively common, no synthetic molecular knot had been obtained until recently. Here again, the success of the synthetic approach relies on the use of transition metals as templating species. Multinuclear double-stranded helices are interesting intermediate compounds which should allow the preparation of molecular knots and catenanes of increasing topological complexity. The first molecular trefoil knot has only been synthesized and fully characterized recently, although theoretical discussions on chemical knots were published over thirty years ago.
DNA 的遗传重排产生具有独特拓扑结构的结：对突触和交叉机制的影响。
DOI：
10.1073/pnas.82.10.3124
发表时间：
1985
影响因子：
11.1
作者：
Griffith,JD;Nash,HA
通讯作者：
Nash,HA
影响因子：
56.9
作者：
WASSERMAN, SA;COZZARELLI, NR
通讯作者：
COZZARELLI, NR
用通用方法测定 Tn3 解离酶产物的立体结构。
DOI：
10.1073/pnas.82.4.1079
发表时间：
1985
影响因子：
11.1
作者：
Wasserman,SA;Cozzarelli,NR
通讯作者：
Cozzarelli,NR