Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers.
Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers.
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DOI：
10.20892/j.issn.2095-3941.2023.0119
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发表时间：
2023-08-08
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
结直肠癌（CRC）仍然是全球人类健康的巨大挑战。不幸的是，CRC进展的潜在机制尚未得到很好的理解。越来越多的证据证实外泌体在结直肠癌的进展中起着至关重要的作用，引起了研究者的广泛关注。除了充当CRC细胞之间的信使外，外泌体还参与CRC免疫调节过程并重塑免疫功能。作为稳定的信息载体和正在开发的液体活检选择，外泌体是诊断或治疗CRC的有希望的生物标志物。本文就exosomes的生物来源和释放以及exosomes在结直肠癌免疫调节和转移中的作用作一综述。此外，我们已经讨论了候选外泌体分子作为诊断CRC、预测CRC进展或确定CRC化疗耐药性的潜在生物标志物，并描述了外泌体在CRC免疫治疗中的意义。这篇综述提供了深入了解外泌体在CRC进展中的作用，并确定了有助于CRC患者临床管理的有价值的生物标志物。
Colorectal cancer (CRC) remains an enormous challenge to human health worldwide. Unfortunately, the mechanism underlying CRC progression is not well understood. Mounting evidence has confirmed that exosomes play a vital role in CRC progression, which has attracted extensive attention among researchers. In addition to acting as messengers between CRC cells, exosomes also participate in the CRC immunomodulatory process and reshape immune function. As stable message carriers and liquid biopsy option under development, exosomes are promising biomarkers in the diagnosis or treatment of CRC. In this review we have described and analyzed the biogenesis and release of exosomes and current research on the role of exosomes in immune regulation and metastasis of CRC. Moreover, we have discussed candidate exosomal molecules as potential biomarkers to diagnose CRC, predict CRC progression, or determine CRC chemoresistance, and described the significance of exosomes in the immunotherapy of CRC. This review provides insight to further understand the role of exosomes in CRC progression and identify valuable biomarkers that facilitate the clinical management of CRC patients.
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影响因子：
29.4
作者：
Boland CR;Goel A
通讯作者：
Goel A
DOI：
10.1016/j.omtn.2020.11.003
发表时间：
2021-06-04
期刊：
Molecular therapy. Nucleic acids
影响因子：
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作者：
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通讯作者：
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影响因子：
9.1
作者：
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通讯作者：
Akar-Ghibril, Nicole
抑制肿瘤的 circRHOBTB3 通过外泌体从细胞中排出，以维持结直肠癌细胞的健康
影响因子：
37.3
作者：
Chen C;Yu H;Han F;Lai X;Ye K;Lei S;Mai M;Lai M;Zhang H
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