Detection and confirmation of the ring-opened carboxylic acid metabolite of a new synthetic opioid furanylfentanyl
Detection and confirmation of the ring-opened carboxylic acid metabolite of a new synthetic opioid furanylfentanyl
复制标题
新型合成阿片类药物呋喃芬太尼开环羧酸代谢物的检测与确证
DOI：
10.1007/s11419-020-00546-7
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Y.T.
中科院分区：
文献类型：
--
作者：
Kanamori;T.;Okada;Y.;Segawa;H.;Yamamuro;T.;Kuwayama;K.;Tsujikawa;K.;Iwata;Y.T.
PurposeRecently, the opioid epidemic has become a serious problem, particularly in North America and Europe. The aim of this study was to clarifyQuery the metabolic fate of a new synthetic opioid furanylfentanyl.MethodsThe metabolism of furanylfentanyl was investigated by incubating fresh human hepatocytes with 10 µM furanylfentanyl at 37 °C for 48 h in an atmosphere of 5% CO2. After incubation, the culture medium was deproteinized and analyzed by liquid chromatography/mass spectrometry.ResultsOn the chromatogram, four metabolites of furanylfentanyl were presumably detected: 4´-hydroxy-furanylfentanyl, β-hydroxy-furanylfentanyl, 4´-hydroxy-3´-methoxy-furanylfentanyl, and a ring-opened carboxylic acid metabolite. These newly found metabolites of furanylfentanyl were then definitely identified using chemically synthesized authentic standards.ConclusionsFour metabolites of furanylfentanyl were newly identified. Although it has been proposed over recent years that a dihydrodiol metabolite, which has the same molecular weight as the ring-opened carboxylic acid metabolite, is formed from furanylfentanyl, this study demonstrated that the ring-opened carboxylic acid metabolite, rather than the dihydrodiol metabolite, is formed from furanylfentanyl.
登录
查看更多内容
从肝脏人源化小鼠中分离的肝细胞对芬太尼和乙酰芬太尼的代谢
DOI：
--
发表时间：
2017
期刊：
影响因子：
--
作者：
Kanamori;T. et al
通讯作者：
T. et al
大剂量输注时芬太尼及其代谢物的尿排泄。
DOI：
--
发表时间：
1986
期刊：
Masui. The Japanese journal of anesthesiology
影响因子：
--
作者：
T. Goromaru;T. Kawauchi;M. Katashima;H. Matsuura;N. Yoshimura;T. Sameshima;T. Miyawaki
通讯作者：
T. Miyawaki
受控物质附表：将呋喃基芬太尼临时纳入附表一。最终命令。
影响因子：
--
作者：
M. J. Lewis
通讯作者：
M. J. Lewis
DOI：
--
发表时间：
1970
期刊：
影响因子：
--
作者：
R. K. Crossland;K. L. Servis
通讯作者：
K. L. Servis
影响因子：
1.7
作者：
Y. Kiso;K. Ukawa;Nakamura Shizuo;Kaoru Ito;T. Akita
通讯作者：
T. Akita