Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied by Brain Dialysis
Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied by Brain Dialysis
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脑透析研究胆碱能药物对大鼠皮层、海马和纹状体细胞外乙酰胆碱和胆碱水平的影响
DOI：
10.1016/0014-2999(89)90510-4
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发表时间：
1989
影响因子：
5
通讯作者：
T. Arima
中科院分区：
文献类型：
--
作者：
K. Toide;T. Arima
The central effects of cholinergie drugs on the release of acetylcholine (ACh) and changes in extracellular choline level were investigated by the brain dialysis technique.Scopolamine (0.5 mg/kg s.c.) markedly increased ACh release in the frontal cortex, hippocampus and corpus striatum. Correspondingly, a significant decrease of choline levels in the extracellular space was observed in the three regions of brain. Oxotremorine (0.5 mg/kg i.p.) displayed almost no effect upon ACh release in the frontal cortex, however, a tendency toward inhibition of ACh release was observed in both the hippocampus and corpus striatum. Conversely, oxotremorine induced an increase of choline levels in both the frontal cortex and hippocampus but not in the corpus striatum. Nicotine (0.5 mg/kg s.c.) displayed a biphasic effect upon ACh release in both the frontal cortex and hippocampus but not in the corpus striatum. No significant changes in the choline levels of these three brain regions were observed after administration of nicotine.The present approach permits the direct detection of changes in ACh and choline levels in the extracellular space of discrete brain areas of experimental animals. These results indicate that thein vivobrain dialysis technique applied to freely moving rats may be useful in investigating cholinergie transmission via presynaptic terminals by means of cholinergic drugs.
受体和磷酸肌醇产生的第二信使。
影响因子：
16.6
作者：
Hokin,LE
通讯作者：
Hokin,LE
影响因子：
56.9
作者：
COYLE, JT;PRICE, DL;DELONG, MR
通讯作者：
DELONG, MR