Robustness: mechanisms and consequences.
Robustness: mechanisms and consequences.
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DOI：
10.1016/j.tig.2009.07.005
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发表时间：
2009-09
影响因子：
11.4
通讯作者：
Siegal, Mark L.
中科院分区：
文献类型：
--
作者：
Masel, Joanna;Siegal, Mark L.
生物系统对突变和环境波动的扰动具有鲁棒性。新的数据揭示了负责鲁棒性的生物化学和网络级机制。对突变的鲁棒性可能是作为一种减少突变影响的适应性进化而来的，也可能是适应性鲁棒性对环境变化的一致副产品，或者是为实现其主要功能而选择的生物系统的内在属性。无论其机制或起源如何，对突变的鲁棒性导致表型隐藏的遗传变异的积累。部分鲁棒性可以导致预适应，从而可能有助于进化。表型电容器的识别和表征-作为鲁棒性程度的开关-对于理解鲁棒性的机制和后果至关重要。
Biological systems are robust to perturbation by mutations and environmental fluctuations. New data are shedding light on the biochemical and network-level mechanisms responsible for robustness. Robustness to mutation might have evolved as an adaptation to reduce the effect of mutations, as a congruent byproduct of adaptive robustness to environmental variation, or as an intrinsic property of biological systems selected for their primary functions. Whatever its mechanism or origin, robustness to mutation results in the accumulation of phenotypically cryptic genetic variation. Partial robustness can lead to pre-adaptation, and thereby might contribute to evolvability. The identification and characterization of phenotypic capacitors — which act as switches of the degree of robustness — are critical to understanding the mechanisms and consequences of robustness.
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