Re-evaluation of mammary stem cell biology based on in vivo transplantation.

Re-evaluation of mammary stem cell biology based on in vivo transplantation.
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基于体内移植的乳腺干细胞生物学的重新评估。

DOI:
10.1186/bcr1856
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发表时间:
2008
影响因子:
7.4
通讯作者:
Medina, Daniel
Medina, Daniel
中科院分区:
医学1区
文献类型:
--
作者:
Smith, Gilbert H.;Medina, Daniel

文献摘要

参考文献

被引文献

相似文献

近半个世纪以来,移植方法已被用来在体内再生乳腺。最近被高度引用的报告声称已经证明了单个乳腺上皮细胞可以再生出整个功能性乳腺。然而,对乳腺再生移植生物学文献的重新审视表明,不同分化的乳腺上皮细胞和乳腺脂肪垫基质之间复杂的组合相互作用对于这一过程是不可或缺的。在本文中,我们对这些问题进行了回顾和讨论,以更好地理解这些多重相互作用的复杂性。
Over nearly half a century, transplantation methods have been employed to regenerate the mammary gland in vivo. Recent highly cited reports claim to have demonstrated the regeneration of an entire functional mammary gland from a single mammary epithelial cell. Nevertheless, re-examination of the literature on the transplantation biology of mammary gland regeneration reveals that a complex, combinatorial interaction between variously differentiated mammary epithelial cells and the mammary fat pad stroma is indispensable to this process. In the present article, these issues are reviewed and discussed to provide a greater understanding of the complexity of these multiplex interactions.
DOI: 10.1093/carcin/14.1.25
发表时间: 1993-01-01
期刊: CARCINOGENESIS
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作者:
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