Histochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide synthase, in neurons of the rat pancreas
Histochemical demonstration of NADPH-diaphorase activity, a marker for nitric oxide synthase, in neurons of the rat pancreas
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大鼠胰腺神经元中 NADPH-心肌黄酶活性（一氧化氮合酶的标志物）的组织化学展示
DOI：
10.1016/0304-3940(92)90806-i
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发表时间：
1992
影响因子：
2.5
通讯作者：
T. Toyota
中科院分区：
文献类型：
--
作者：
T. Shimosegawa;T. Abe;A. Satoh;T. Asakura;Kazumasa Yoshida;M. Koizumi;T. Toyota
为了阐明一氧化氮（NO）在胰腺中的作用，我们组织化学研究了NADPH黄递酶，一氧化氮合酶的标志物，在大鼠胰腺。NADPH-黄递酶活性定位于神经元和血管内皮细胞。外分泌和内分泌胰腺内均可见具有NADPH-黄递酶活性的神经纤维，主要与血管系统有关。胰腺实质内的大多数神经细胞体（98.5%）表现出较强的活性。这些结果表明，NO可能参与胰腺的血流动力学控制和胰腺外分泌和内分泌功能的神经调节。
To clarify the role of nitric oxide (NO) in the pancreas, we histochemically investigated NADPH-diaphorase, a marker for NO synthase, in the rat pancreas. NADPH-diaphorase activity was localized in the neurons and endothelium of vessels. The nerve fibers with NADPH-diaphorase activity were observed in both the exocrine and the endocrine pancreas associated chiefly with the vascular systems. Most nerve cell bodies (98.5%) within the pancreatic parenchyma showed strong activity for this enzyme. These results suggest that NO may participate in the hemodynamic control of the pancreas and in the neuronal regulation of pancreatic exocrine and endocrine functions.
影响因子：
56.9
作者：
SCHMIDT, HHHW;WARNER, TD;MURAD, F
通讯作者：
MURAD, F
DOI：
10.1073/pnas.88.17.7797
发表时间：
1991-09-01
影响因子：
11.1
作者：
DAWSON, TM;BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH