Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.
Epigenetic Matters: The Link between Early Nutrition, Microbiome, and Long-term Health Development.
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表观遗传问题：早期营养，微生物组和长期健康发展之间的联系。
DOI：
10.3389/fped.2017.00178
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发表时间：
2017
影响因子：
2.6
通讯作者：
Loverro G
中科院分区：
文献类型：
--
作者：
Indrio F;Martini S;Francavilla R;Corvaglia L;Cristofori F;Mastrolia SA;Neu J;Rautava S;Russo Spena G;Raimondi F;Loverro G
表观遗传修饰是最重要的机制之一，通过这种机制，环境因素可以影响早期细胞分化，并在怀孕期间和新生儿时期创造新的表型特征，而不会改变脱氧核糖核酸序列。许多产前和出生后的因素，如母亲和新生儿的营养、污染物暴露和微生物区系的组成，有助于建立表观遗传变化，这些变化不仅可以调节个人对环境的适应，而且通过改变炎症分子通路和免疫反应对终身健康和疾病产生影响。出生后的肠道定植又由母亲的菌群、分娩方式、早期皮肤接触和新生儿饮食决定，导致特定的表观遗传特征，这些特征可以影响肠道粘膜的屏障特性及其对以后的侮辱的保护作用，从而潜在地易于发生迟发性炎症性疾病。这篇综述的目的是概述在早期生命阶段起作用的规划和发育的表观遗传学机制，并详细检查母亲和新生儿营养、微生物区系组成和其他环境因素在决定表观遗传学变化及其短期和长期影响中的作用。
Epigenetic modifications are among the most important mechanisms by which environmental factors can influence early cellular differentiation and create new phenotypic traits during pregnancy and within the neonatal period without altering the deoxyribonucleic acid sequence. A number of antenatal and postnatal factors, such as maternal and neonatal nutrition, pollutant exposure, and the composition of microbiota, contribute to the establishment of epigenetic changes that can not only modulate the individual adaptation to the environment but also have an influence on lifelong health and disease by modifying inflammatory molecular pathways and the immune response. Postnatal intestinal colonization, in turn determined by maternal flora, mode of delivery, early skin-to-skin contact and neonatal diet, leads to specific epigenetic signatures that can affect the barrier properties of gut mucosa and their protective role against later insults, thus potentially predisposing to the development of late-onset inflammatory diseases. The aim of this review is to outline the epigenetic mechanisms of programming and development acting within early-life stages and to examine in detail the role of maternal and neonatal nutrition, microbiota composition, and other environmental factors in determining epigenetic changes and their short- and long-term effects.
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影响因子：
14.2
作者：
Brand, Stephanie;Teich, Rene;Renz, Harald
通讯作者：
Renz, Harald
影响因子：
6.1
作者：
Anderson, Cindy M.;Ralph, Jody L.;Uthus, Eric
通讯作者：
Uthus, Eric
影响因子：
5.6
作者：
Burris, Heather H.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
通讯作者：
Gillman, Matthew W.
影响因子：
64.5
作者：
Cox LM;Yamanishi S;Sohn J;Alekseyenko AV;Leung JM;Cho I;Kim SG;Li H;Gao Z;Mahana D;Zárate Rodriguez JG;Rogers AB;Robine N;Loke P;Blaser MJ
通讯作者：
Blaser MJ
早期生命中的抗生素改变了肠道微生物组并增加了自身免疫胰岛素依赖性糖尿病的自发小鼠模型。
影响因子：
3.7
作者：
Candon S;Perez-Arroyo A;Marquet C;Valette F;Foray AP;Pelletier B;Milani C;Ventura M;Bach JF;Chatenoud L
通讯作者：
Chatenoud L