The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning.
The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning.
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DOI：
10.1038/nn.2235
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发表时间：
2009-01
影响因子：
25
通讯作者：
Davis, Ronald L.
中科院分区：
文献类型：
--
作者：
Liu, Xu;Davis, Ronald L.
GABA能神经递质系统对许多认知过程都很重要，包括学习和记忆。我们在果蝇大脑的每个半球都发现了一个单一的神经元--前成对外侧（APL）神经元--它是一个广泛支配蘑菇体的GABA能神经元。减少GABA合成的APL神经元增强嗅觉学习，这表明APL抑制学习通过释放抑制性神经递质GABA。功能光学成像实验表明，APL反应的气味和电击刺激呈现给苍蝇与细胞内钙和释放的神经递质的增加。更重要的是，通过将气味与电击配对，在APL神经元中形成了记忆痕迹。这种痕迹被检测为减少钙反应APL后，专门训练的气味条件。这些结果表明，GABA能APL神经元和嗅觉学习之间的相互抑制和GABA能系统的功能性神经可塑性由于学习。
GABAergic neurotransmitter systems are important for many cognitive processes, including learning and memory. We identified a single neuron in each hemisphere of the Drosophila brain - the anterior paired lateral (APL) neuron - as a GABAergic neuron that broadly innervated the mushroom bodies. Reducing GABA synthesis in the APL neuron enhanced olfactory learning, suggesting that APL suppressed learning by releasing the inhibitory neurotransmitter GABA. Functional optical imaging experiments revealed that APL responded to both odor and electric shock stimuli presented to the fly with increases of intracellular calcium and released neurotransmitter. More importantly, a memory trace formed in the APL neuron by pairing odor with electric shock. This trace was detected as a reduced calcium response in APL after conditioning specifically to the trained odor. These results demonstrated a mutual suppression between the GABAergic APL neuron and olfactory learning, and functional neuroplasticity of the GABAergic system due to learning.
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影响因子：
5.3
作者：
Wang, Yalin;Mamiya, Akira;Zhong, Yi
通讯作者：
Zhong, Yi
影响因子：
9.2
作者：
Riemensperger, T;Völler, T;Fiala, A
通讯作者：
Fiala, A
DOI：
10.1007/s003590050417
发表时间：
1999-12-01
影响因子：
2.1
作者：
Grünewald, B
通讯作者：
Grünewald, B
影响因子：
64.5
作者：
Marin, EC;Jefferis, GSXE;Luo, LQ
通讯作者：
Luo, LQ
影响因子：
16.2
作者：
Chevaleyre, V;Castillo, PE
通讯作者：
Castillo, PE