Genetic risk and age in Parkinson's disease: Continuum not stratum.
Genetic risk and age in Parkinson's disease: Continuum not stratum.
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DOI：
10.1002/mds.26192
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发表时间：
2015-05
影响因子：
8.6
通讯作者：
Singleton, Andrew B.
中科院分区：
文献类型：
--
作者：
Nalls, Mike A.;Escott-Price, Valentina;Williams, Nigel M.;Lubbe, Steven;Keller, Margaux F.;Morris, Huw R.;Singleton, Andrew B.
最近的全基因组关联研究荟萃分析已经确定了28个与帕金森病（PD）风险相关的基因座。我们试图调查这些遗传危险因素是否与帕金森病发病年龄相关。计算了6249例病例的这些基因座的遗传风险评分。线性回归检验了累积遗传风险与PD发病年龄之间的相关性。遗传风险评分增加与发病年龄较早相关（β =-0.10，p值= 2.92E-08，校正r2 = 0.27）。遗传风险评分的单个标准差增加与发病年龄提前37.44天相关。最高的遗传风险发生在31-60岁，发病率略低于平均水平，最年轻和最老的群体表现出最不常见的变异衍生的遗传风险。
Recent genome-wide association study meta-analyses have identified 28 loci associated with risk of Parkinson’s disease (PD). We sought to investigate if these genetic risk factors are associated with PD age at onset. Genetic risk scores from these loci were calculated for 6249 cases. Linear regression tested associations between cumulative genetic risk and PD age at onset. Increasing genetic risk scores were associated with earlier age at onset (beta = −0.10, p-value = 2.92E-08, adjusted r2 = 0.27). Single standard deviation increase in genetic risk score is associated with 37.44 days earlier age at onset. Highest genetic risk was found at 31–60 years, onset slightly below average, with youngest and oldest groups exhibiting the least common variant derived genetic risk.
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影响因子：
3.7
作者：
Hernandez DG;Nalls MA;Ylikotila P;Keller M;Hardy JA;Majamaa K;Singleton AB
通讯作者：
Singleton AB
影响因子：
8.6
作者：
Wickremaratchi, Mirdhu M.;Knipe, M. Duleeka W.;Morris, Huw R.
通讯作者：
Morris, Huw R.
影响因子：
30.8
作者：
Nalls, Mike A.;Pankratz, Nathan;Lill, Christina M.;Do, Chuong B.;Hernandez, Dena G.;Saad, Mohamad;DeStefano, Anita L.;Kara, Eleanna;Bras, Jose;Sharma, Manu;Schulte, Claudia;Keller, Margaux F.;Arepalli, Sampath;Letson, Christopher;Edsall, Connor;Stefansson, Hreinn;Liu, Xinmin;Pliner, Hannah;Lee, Joseph H.;Cheng, Rong;Ikram, M. Arfan;Ioannidis, John P. A.;Hadjigeorgiou, Georgios M.;Bis, Joshua C.;Martinez, Maria;Perlmutter, Joel S.;Goate, Alison;Marder, Karen;Fiske, Brian;Sutherland, Margaret;Xiromerisiou, Georgia;Myers, Richard H.;Clark, Lorraine N.;Stefansson, Kari;Hardy, John A.;Heutink, Peter;Chen, Honglei;Wood, Nicholas W.;Houlden, Henry;Payami, Haydeh;Brice, Alexis;Scott, William K.;Gasser, Thomas;Bertram, Lars;Eriksson, Nicholas;Foroud, Tatiana;Singleton, Andrew B.
通讯作者：
Singleton, Andrew B.
影响因子：
3.5
作者：
Chio, Adriano;Schymick, Jennifer C.;Traynor, Bryan J.
通讯作者：
Traynor, Bryan J.
影响因子：
168.9
作者：
Ripatti, Samuli;Tikkanen, Emmi;Orho-Melander, Marju;Havulinna, Aki S.;Silander, Kaisa;Sharma, Amitabh;Guiducci, Candace;Perola, Markus;Jula, Antti;Sinisalo, Juha;Lokki, Marja-Liisa;Nieminen, Markku S.;Melander, Olle;Salomaa, Veikko;Peltonen, Leena;Kathiresan, Sekar
通讯作者：
Kathiresan, Sekar