Building complexity: insights into self-organized assembly of microtubule-based architectures.
Building complexity: insights into self-organized assembly of microtubule-based architectures.
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DOI：
10.1016/j.devcel.2012.10.011
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发表时间：
2012-11-13
影响因子：
11.8
通讯作者：
Kapoor TM
中科院分区：
文献类型：
--
作者：
Subramanian R;Kapoor TM
多种细胞功能的成功完成，如有丝分裂、细胞器定位和纤毛组装，依赖于微管结构的正确组装。虽然组装这些结构所需的所有蛋白质现在都是已知的，但我们甚至无法解释大小和形状等基本特征是如何决定的。作为填补这一知识空白的步骤，最近已经有几项努力，试图用纯化的蛋白质重组在不同细胞骨架阵列中重复出现的基本结构基序。我们讨论这些研究，并强调它们如何揭示复杂和动态的基于细胞骨架的细胞结构的自组织组装。
Successful completion of diverse cellular functions, such as mitosis, positioning organelles, and assembling cilia, depends on the proper assembly of microtubule-based structures. While essentially all of the proteins needed to assemble these structures are now known, we cannot explain how even basic features such as size and shape are determined. As steps towards filling this knowledge gap, there have been several recent efforts towards reconstituting, with purified proteins, the basic structural motifs that recur in diverse cytoskeletal arrays. We discuss these studies and highlight how they shed light on the self-organized assembly of complex and dynamic cytoskeleton-based cellular structures.
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影响因子：
11.8
作者：
Al-Bassam, Jawdat;Kim, Hwajin;Brouhard, Gary;van Oijen, Antoine;Harrison, Stephen C.;Chang, Fred
通讯作者：
Chang, Fred
影响因子：
64.5
作者：
Akhmanova, A;Hoogenraad, CC;Galjart, N
通讯作者：
Galjart, N
影响因子：
21.3
作者：
Fukata, Y;Itoh, TJ;Kaibuchi, K
通讯作者：
Kaibuchi, K
DOI：
10.1083/jcb.135.2.399
发表时间：
1996-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gaglio T;Saredi A;Bingham JB;Hasbani MJ;Gill SR;Schroer TA;Compton DA
通讯作者：
Compton DA
影响因子：
21.3
作者：
Braun, Marcus;Lansky, Zdenek;Janson, Marcel E.
通讯作者：
Janson, Marcel E.