Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study.
Portable air cleaners and residential exposure to SARS-CoV-2 aerosols: A real-world study.
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DOI：
10.1111/ina.13029
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发表时间：
2022-04
期刊：
影响因子：
5.8
通讯作者：
Kipen, Howard M.
中科院分区：
文献类型：
--
作者：
Myers, Nirmala T.;Laumbach, Robert J.;Black, Kathleen G.;Ohman-Strickland, Pamela;Alimokhtari, Shahnaz;Legard, Alicia;De Resende, Adriana;Calderon, Leonardo;Lu, Frederic T.;Mainelis, Gediminas;Kipen, Howard M.
关键词：
不需要住院治疗的 COVID-19 患者将被指示在其住所进行自我隔离。由于家庭成员的继发感染率较高，因此有必要了解住宅内 SARS-CoV-2 的空气传播情况。我们报告的第一项自然干预研究表明，使用带有 HEPA 过滤器的便携式空气净化器 (PAC) 可以降低此类传播风险。 17 名新诊断出的 COVID-19 感染者完成了这项单盲、交叉、随机研究。在带有 PAC（主要）的自我隔离室和另一个房间（次要）连续两个 24 小时内同时收集总气溶胶样本和大小分级气溶胶样本，其中一个时期使用 HEPA 过滤，另一个时期移除过滤器（假）。在假手术期间，主房间的 16 个空气样本中有 7 个 (44%) 呈 SARS-CoV-2 RNA 阳性。由于 PAC 在最低设置（清洁空气输送率 [CADR] = 263 cfm）下运行以最大程度地减少噪音，16 个住宅中的阳性气溶胶样本减少到了 4 个（25%；p = 0.229）。在二级房间中还观察到阳性气溶胶样本略有减少。由于世界面临着新的变异和有限的疫苗接种率，我们的研究支持这种实际干预措施，以减少现实世界中病毒气溶胶的存在。
Individuals with COVID‐19 who do not require hospitalization are instructed to self‐isolate in their residences. Due to high secondary infection rates in household members, there is a need to understand airborne transmission of SARS‐CoV‐2 within residences. We report the first naturalistic intervention study suggesting a reduction of such transmission risk using portable air cleaners (PACs) with HEPA filters. Seventeen individuals with newly diagnosed COVID‐19 infection completed this single‐blind, crossover, randomized study. Total and size‐fractionated aerosol samples were collected simultaneously in the self‐isolation room with the PAC (primary) and another room (secondary) for two consecutive 24‐h periods, one period with HEPA filtration and the other with the filter removed (sham). Seven out of sixteen (44%) air samples in primary rooms were positive for SARS‐CoV‐2 RNA during the sham period. With the PAC operated at its lowest setting (clean air delivery rate [CADR] = 263 cfm) to minimize noise, positive aerosol samples decreased to four out of sixteen residences (25%; p = 0.229). A slight decrease in positive aerosol samples was also observed in the secondary room. As the world confronts both new variants and limited vaccination rates, our study supports this practical intervention to reduce the presence of viral aerosols in a real‐world setting.
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影响因子：
11.8
作者：
Cheng, Vincent Chi-Chung;Fung, Kitty Sau-Chun;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
11.8
作者：
Bullard, Jared;Dust, Kerry;Poliquin, Guillaume
通讯作者：
Poliquin, Guillaume
影响因子：
--
作者：
Butz AM;Matsui EC;Breysse P;Curtin-Brosnan J;Eggleston P;Diette G;Williams D;Yuan J;Bernert JT;Rand C
通讯作者：
Rand C
影响因子：
11.8
作者：
Chirizzi D;Conte M;Feltracco M;Dinoi A;Gregoris E;Barbaro E;La Bella G;Ciccarese G;La Salandra G;Gambaro A;Contini D
通讯作者：
Contini D
DOI：
10.1038/sj.jes.7500640
发表时间：
2008-09-01
影响因子：
4.5
作者：
Barn, Prabjit;Larson, Timothy;Brauer, Michael
通讯作者：
Brauer, Michael