On the Role and Effects of Uncertainties in Cardiovascular in silico Analyses.
On the Role and Effects of Uncertainties in Cardiovascular in silico Analyses.
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DOI：
10.3389/fmedt.2021.748908
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发表时间：
2021
影响因子：
--
通讯作者：
Gasparotti E
中科院分区：
文献类型：
--
作者：
Celi S;Vignali E;Capellini K;Gasparotti E
心血管血流动力学与计算技术的评估正在建立其在现代临床世界的基本贡献。大的研究兴趣集中在主动脉血管上。对主动脉血流、压力和应力的研究是理解动脉瘤等复杂病理的基础。然而，计算方法仍然受到误差和不确定性来源的影响。这些现象发生在不同层次的计算分析，他们也强烈地依赖于所采用的方法的类型。在当前研究中，描述了主动脉病例的误差源影响。特别是，在计算分析中采用的心动周期的不同阶段分割患者特定主动脉结构的几何形状。不同程度的表面平滑施加，以确定其对数值结果的影响。在此之后，三种不同的模拟方法施加在相同的几何形状：刚性壁计算流体动力学（CFD），基于径向基函数（RBF）CFD的移动壁CFD，和流体-结构相互作用（FSI）模拟。在壁面剪应力（WSS）分析方面定义了所实施方法的差异。特别是，对于报告的所有病例，定义了收缩期WSS和时间平均WSS（TAWSS）。
The assessment of cardiovascular hemodynamics with computational techniques is establishing its fundamental contribution within the world of modern clinics. Great research interest was focused on the aortic vessel. The study of aortic flow, pressure, and stresses is at the basis of the understanding of complex pathologies such as aneurysms. Nevertheless, the computational approaches are still affected by sources of errors and uncertainties. These phenomena occur at different levels of the computational analysis, and they also strongly depend on the type of approach adopted. With the current study, the effect of error sources was characterized for an aortic case. In particular, the geometry of a patient-specific aorta structure was segmented at different phases of a cardiac cycle to be adopted in a computational analysis. Different levels of surface smoothing were imposed to define their influence on the numerical results. After this, three different simulation methods were imposed on the same geometry: a rigid wall computational fluid dynamics (CFD), a moving-wall CFD based on radial basis functions (RBF) CFD, and a fluid-structure interaction (FSI) simulation. The differences of the implemented methods were defined in terms of wall shear stress (WSS) analysis. In particular, for all the cases reported, the systolic WSS and the time-averaged WSS (TAWSS) were defined.
影响因子：
2.4
作者：
Bosi GM;Biffi B;Biglino G;Lintas V;Jones R;Tzamtzis S;Burriesci G;Migliavacca F;Khambadkone S;Taylor AM;Schievano S
通讯作者：
Schievano S