Location and cellular stages of natural killer cell development.

Location and cellular stages of natural killer cell development.
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DOI:
10.1016/j.it.2013.07.005
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发表时间:
2013-12
影响因子:
16.8
通讯作者:
Caligiuri MA
Caligiuri MA
中科院分区:
医学1区
文献类型:
--
作者:
Yu J;Freud AG;Caligiuri MA

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不同的组织特异性自然杀伤(NK)细胞群体,显然从当地的前体人群成熟的鉴定带来了新的见解的多样性和发展调节这一重要的淋巴亚群。NK细胞在对感染的早期(先天)和晚期(适应性)免疫应答之间提供了必要的联系。更好地了解NK细胞发育的过程应该使我们能够在多种临床环境中更好地利用NK细胞功能,并进一步了解这些细胞如何发生恶性转化。在这篇综述中,我们总结了最近的进展,了解网站和细胞阶段的NK细胞在人类和小鼠的发展。
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to better harness NK cell functions in multiple clinical settings as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice.
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