Location and cellular stages of natural killer cell development.
Location and cellular stages of natural killer cell development.
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DOI:
10.1016/j.it.2013.07.005
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发表时间:
2013-12
影响因子:
16.8
通讯作者:
Caligiuri MA
中科院分区:
文献类型:
--
作者:
Yu J;Freud AG;Caligiuri MA
The identification of distinct tissue-specific natural killer (NK) cell populations that apparently mature from local precursor populations has brought new insight into the diversity and developmental regulation of this important lymphoid subset. NK cells provide a necessary link between the early (innate) and late (adaptive) immune responses to infection. Gaining a better understanding of the processes that govern NK cell development should allow us to better harness NK cell functions in multiple clinical settings as well as to gain further insight into how these cells undergo malignant transformation. In this review, we summarize recent advances in understanding sites and cellular stages of NK cell development in humans and mice.
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