TGF-β affects development and differentiation of human natural killer cell subsets.
TGF-β affects development and differentiation of human natural killer cell subsets.
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DOI：
10.1002/eji.200939910
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发表时间：
2010-08
影响因子：
5.4
通讯作者：
Strominger, Jack L.
中科院分区：
文献类型：
--
作者：
Allan, David S. J.;Rybalov, Basya;Awong, Geneve;Zuniga-Pfluecker, Juan Carlos;Kopcow, Hernan D.;Carlyle, James R.;Strominger, Jack L.
人类外周血NK细胞可分为两个主要亚群：CD 56 brightCD 16 −和CD 56 dimCD 16+。由于已知TGF-β影响许多白细胞谱系的发育，因此研究了其对体外人CD 34 +Lin−造血祖细胞/干细胞或外周血NK细胞的NK细胞分化的影响。TGF-β抑制NK细胞从CD 34+祖细胞的发育并抑制CD 16 + NK细胞的分化。此外，TGF-β还导致外周血中发现的一小部分CD 56 brightCD 16+细胞转化为CD 56 brightCD 16 −细胞，突出了前者作为发育中间体和TGF-β影响血液中发现的NK亚群发生的可能作用。
Human peripheral blood NK cells may be divided into two main subsets: CD56brightCD16− and CD56dimCD16+. Since TGF-β is known to influence the development of many leukocyte lineages, its effects on NK cell differentiation either from human CD34+Lin− hematopoietic progenitor/stem cells in vitro or from peripheral blood NK cells were investigated. TGF-β represses development of NK cells from CD34+ progenitors and inhibits differentiation of CD16+ NK cells. Moreover, TGF-β also results in conversion of a minor fraction of CD56brightCD16+ cells found in peripheral blood into CD56brightCD16− cells, highlighting a possible role of the former as a developmental intermediate and of TGF-β in influencing the genesis of NK subsets found in blood.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
100.3
作者：
Vivier, Eric;Spits, Hergen;Cupedo, Tom
通讯作者：
Cupedo, Tom
影响因子：
5.5
作者：
Eriksson, M;Meadows, SK;Sentman, CL
通讯作者：
Sentman, CL
影响因子：
20.3
作者：
La Motte-Mohs, RN;Herer, E;Zúñiga-Pflücker, JC
通讯作者：
Zúñiga-Pflücker, JC
影响因子：
20.3
作者：
Fehniger, TA;Cooper, MA;Caligiuri, MA
通讯作者：
Caligiuri, MA