Integrating Sister Chromatid Cohesion Establishment to DNA Replication.
Integrating Sister Chromatid Cohesion Establishment to DNA Replication.
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作者：
两个基本过程的交汇点为观察细胞调控提供了一个独特的Vantage位置。一方面，DNA复制是细胞分裂的核心，产生重复的染色体，使每个子细胞继承亲本基因组的完整拷贝。在其他因素中，PCNA（增殖细胞核抗原）滑动夹确保S期期间的进行性DNA复制，并且对细胞活力至关重要。另一方面，在M期染色体分离的过程--一个发生在DNA复制之后很久的行为--对成功的细胞分裂同样重要。Eco 1/Ctf 7确保染色体在有丝分裂过程中忠实地分离，但在DNA复制过程中起作用，以激活凝聚素，从而在姐妹染色单体之间建立凝聚力。为了实现这一点，Eco 1结合PCNA和许多其他DNA复制叉因子，包括MCM解旋酶，Chl 1解旋酶和Rtt 101-Mms 1-Mms 22 E3泛素连接酶。在这里，我们回顾了凝聚力的建立和DNA复制之间的多方面的协调。摘要声明：新的发现为DNA复制和姐妹染色单体凝聚力的建立耦合的机制提供了重要的见解。
The intersection through which two fundamental processes meet provides a unique vantage point from which to view cellular regulation. On the one hand, DNA replication is at the heart of cell division, generating duplicate chromosomes that allow each daughter cell to inherit a complete copy of the parental genome. Among other factors, the PCNA (proliferating cell nuclear antigen) sliding clamp ensures processive DNA replication during S phase and is essential for cell viability. On the other hand, the process of chromosome segregation during M phase—an act that occurs long after DNA replication—is equally fundamental to a successful cell division. Eco1/Ctf7 ensures that chromosomes faithfully segregate during mitosis, but functions during DNA replication to activate cohesins and thereby establish cohesion between sister chromatids. To achieve this, Eco1 binds PCNA and numerous other DNA replication fork factors that include MCM helicase, Chl1 helicase, and the Rtt101-Mms1-Mms22 E3 ubiquitin ligase. Here, we review the multi-faceted coordination between cohesion establishment and DNA replication. SUMMARY STATEMENT: New findings provide important insights into the mechanisms through which DNA replication and the establishment of sister chromatid cohesion are coupled.
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DOI：
10.1007/s00018-014-1569-4
发表时间：
2014-07
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Bharti SK;Khan I;Banerjee T;Sommers JA;Wu Y;Brosh RM Jr
通讯作者：
Brosh RM Jr
影响因子：
4.5
作者：
Cortone G;Zheng G;Pensieri P;Chiappetta V;Tatè R;Malacaria E;Pichierri P;Yu H;Pisani FM
通讯作者：
Pisani FM
影响因子：
4.8
作者：
Antoniacci, LM;Kenna, MA;Skibbens, RV
通讯作者：
Skibbens, RV
影响因子：
64.5
作者：
Ciosk, R;Zachariae, W;Nasmyth, K
通讯作者：
Nasmyth, K
影响因子：
9.8
作者：
Deardorff, Matthew A.;Kaur, Maninder;Krantz, Ian D.
通讯作者：
Krantz, Ian D.