Motoneuron projection patterns in chick embryonic limbs with a double complement of dorsal thigh musculature.
Motoneuron projection patterns in chick embryonic limbs with a double complement of dorsal thigh musculature.
复制标题
鸡胚胎四肢的运动神经元投射模式与大腿背侧肌肉组织的双重补充。
DOI：
10.1016/0012-1606(86)90141-7
复制
发表时间：
1986
影响因子：
2.7
通讯作者：
C. Lance‐Jones
中科院分区：
文献类型：
--
作者：
C. Lance‐Jones
在雏鸡的正常发育过程中，脊髓腰骶运动柱内的外侧运动神经元始终如一地投射到肢体背侧起始肌，而内侧运动神经元投射到腹侧起始肌。为了确定来自每种目标的特定线索是否是外侧和内侧运动神经元用来创建这种模式的主导引导线索，我研究了大腿背侧肌肉系统的双重补充而没有腹侧肌肉系统的鸡胚胎肢体的运动神经元投射。结果表明，与特定发育来源的肌肉相关的暗示并不总是占主导地位。在运动神经元死亡的主要时期之前和之后，背肢区(宿主)的所有肌肉都由外侧池神经元或背池神经元支配。大多数腹侧(供体)肌由内侧池或腹侧池神经元支配。只有供体髂腓肌--一块距离其原始神经来源非常近的肌肉--接受了一些外侧神经元的投射。在肢体内部，内侧或腹侧池神经元以一种有模式的方式投射到供体肌肉，这表明它们遵循非特定的区域线索，可能也对未神经支配的靶组织的可用性做出反应。我的结论是，轴突分为不同的外侧和内侧分类独立于肢体目标补体，随后的路径选择是一个独立的事件，由特定的目标线索和其他指导机制共同控制。
During the normal development of the chick, lateral motoneurons within the lumbosacral motor column of the spinal cord consistently project to muscles of dorsal origin within the limb while medial motoneurons project to muscles of ventral origin. To determine if specific cues arising from each type of target are the dominant guidance cues used by lateral and medial motoneurons to create this pattern, I examined motoneuron projections in embryonic chick limbs with a double complement of dorsal thigh musculature and no ventral musculature. Results indicate that cues associated with muscles of a specific developmental origin do not invariably dominate. Before and after the major period of motoneuron death, all muscles in dorsal limb regions (host) were innervated by lateral or dorsal pool neurons. Most ventrally positioned (donor) muscles were innervated by medial or ventral pool neurons. Only the donor iliofibularis, a muscle located very near to its original source of innervation, received projections from some lateral neurons. Within the limb proper, medial or ventral pool neurons projected to donor muscles in a patterned manner suggesting that they were following nonspecific regional cues and perhaps also responding to the availability of uninnervated target tissue. I conclude that axon sorting into distinct lateral and medial classes is independent of limb target complement and that subsequent pathway choice is a separate event governed by both specific target cues and other guidance mechanisms.
雏鸡四肢运动神经支配的发育。
DOI：
--
发表时间：
1983
期刊：
Progress in clinical and biological research
影响因子：
--
作者：
Hollyday,M
通讯作者：
Hollyday,M
影响因子：
2.7
作者：
Tosney,KW;Landmesser,LT
通讯作者：
Landmesser,LT
DOI：
--
发表时间：
1982
期刊：
Journal of embryology and experimental morphology
影响因子：
--
作者：
Rowe,DA;Fallon,JF
通讯作者：
Fallon,JF