Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms.
Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms.
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DOI：
10.1016/j.bpsc.2021.07.014
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发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
Barzilay R
中科院分区：
文献类型：
--
作者：
Alexander-Bloch AF;Sood R;Shinohara RT;Moore TM;Calkins ME;Chertavian C;Wolf DH;Gur RC;Satterthwaite TD;Gur RE;Barzilay R
强迫症(OCS)在青春期很常见，但通常不符合强迫症的诊断门槛。然而，强迫症和阈值下OCS都与经历其他严重精神疾病的可能性增加有关，包括抑郁和自杀意念。不幸的是，关于OCS的神经生物学信息有限。在这里，我们对来自费城神经发育队列的大量青少年样本(分析n=832)进行了第一批OCS的脑成像研究之一。我们使用互补的分析方法来研究静息状态的功能连接，这些方法侧重于不同的神经解剖学尺度，从已知的功能系统到连接组范围的测试。我们发现了连接组范围内与OCS相关的差异的强健模式，以及涉及已知功能系统的特定异常的证据，包括背侧和腹侧注意、额顶和默认模式系统。脑灌注成像和高分辨率结构成像的分析没有显示OCS相关的差异，这与功能连接的领域特异性一致。本文报告的与OCS的脑连接相关，以及对其临床相关性的早期研究，支持OCS作为精神风险的早期标记的潜力，这可能会增强我们对青少年精神病理学发病机制的理解。
Obsessive compulsive symptomatology (OCS) is common in adolescence but usually does not meet the diagnostic threshold for obsessive compulsive disorder. Nevertheless, both OCD and subthreshold OCS are associated with increased likelihood of experiencing other serious psychiatric conditions including depression and suicidal ideation. Unfortunately, there is limited information on the neurobiology of OCS. Here we undertook one of the first brain imaging studies of OCS in a large adolescent sample (analyzed n=832) from the Philadelphia Neurodevelopmental Cohort. We investigated resting-state fMRI functional connectivity using complementary analytic approaches that focus on different neuroanatomical scales, from known functional systems to connectome-wide tests. We found a robust pattern of connectome-wide, OCS-related differences, as well as evidence of specific abnormalities involving known functional systems, including dorsal and ventral attention, frontoparietal and default mode systems. Analysis of cerebral perfusion imaging and high resolution structural imaging did not show OCS-related differences, consistent with domain specificity to functional connectivity. The brain connectomic associations with OCS reported here, together with early studies of its clinical relevance, support the potential for OCS as an early marker of psychiatric risk that may enhance our understanding of mechanisms underlying the onset of adolescent psychopathology.
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DOI：
10.1016/j.jaac.2018.06.038
发表时间：
2019-02-01
影响因子：
13.3
作者：
Barzilay, Ran;Patrick, Ariana;Gur, Raquel E.
通讯作者：
Gur, Raquel E.
影响因子：
7.6
作者：
Allegrini, Andrea G.;Cheesman, Rosa;Plomin, Robert
通讯作者：
Plomin, Robert
影响因子：
17.7
作者：
Fullana, Miguel A.;Mataix-Cols, David;Poulton, Richie
通讯作者：
Poulton, Richie
DOI：
10.1080/15374410903258975
发表时间：
2009-01-01
影响因子：
4.2
作者：
Canavera, Kristin E.;Wilkins, Kendall C.;Ehrenreich-May, Jill T.
通讯作者：
Ehrenreich-May, Jill T.
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC