Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.
Congenital Hypothyroidism: A 2020-2021 Consensus Guidelines Update-An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology.
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先天性甲状腺功能减退症：2020-2021年共识指南更新-欧洲儿科内分泌学会和欧洲内分泌学会支持的ENDO-欧洲参考网络倡议。
DOI：
10.1089/thy.2020.0333
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Polak M
中科院分区：
文献类型：
--
作者：
van Trotsenburg P;Stoupa A;Léger J;Rohrer T;Peters C;Fugazzola L;Cassio A;Heinrichs C;Beauloye V;Pohlenz J;Rodien P;Coutant R;Szinnai G;Murray P;Bartés B;Luton D;Salerno M;de Sanctis L;Vigone M;Krude H;Persani L;Polak M
背景资料：欧洲内分泌参考网（ERN）倡议得到了欧洲儿科内分泌学会和欧洲内分泌学会的认可，来自ENDO-ERN和这两个学会的22名参与者参加了该倡议。目的是更新先天性甲状腺功能减退症（CH）诊断和治疗的实践指南。进行了系统的文献检索，以确定关键文章的新生儿筛查，诊断和管理的主要和中央CH。循证指南进行了分级的建议，评估，发展和评价系统，描述的强度的建议和证据的质量。在缺乏充分证据的情况下，结论是以专家意见为依据的。总结：建议包括各种新生儿筛查方法CH以及病因当CH被诊断时，专家小组建议立即开始正确剂量的左旋甲状腺素治疗和频繁的随访，包括实验室检测，以保持甲状腺激素水平在其目标范围内，及时评估是否需要继续治疗，注意神经发育和神经感觉功能，必要时咨询其他卫生专业人员，并对儿童和家庭进行CH教育。诊断，治疗和随访的协调将优化患者的结局。最后，所有患有CH的人都有权获得从儿科到成人医学的精心计划的护理过渡。结论：根据最新的证据，这一共识指南更新应用于进一步优化所有形式CH儿童的检测、诊断、治疗和随访。它应该是有助于说服卫生当局的新生儿筛查CH的好处。需要进一步的流行病学和实验研究，以了解这种情况的发病率增加。
Background: An ENDO-European Reference Network (ERN) initiative was launched that was endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology with 22 participants from the ENDO-ERN and the two societies. The aim was to update the practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). A systematic literature search was conducted to identify key articles on neonatal screening, diagnosis, and management of primary and central CH. The evidence-based guidelines were graded with the Grading of Recommendations, Assessment, Development and Evaluation system, describing both the strength of recommendations and the quality of evidence. In the absence of sufficient evidence, conclusions were based on expert opinion. Summary: The recommendations include the various neonatal screening approaches for CH as well as the etiology (also genetics), diagnostics, treatment, and prognosis of both primary and central CH. When CH is diagnosed, the expert panel recommends the immediate start of correctly dosed levothyroxine treatment and frequent follow-up including laboratory testing to keep thyroid hormone levels in their target ranges, timely assessment of the need to continue treatment, attention for neurodevelopment and neurosensory functions, and, if necessary, consulting other health professionals, and education of the child and family about CH. Harmonization of diagnostics, treatment, and follow-up will optimize patient outcomes. Lastly, all individuals with CH are entitled to a well-planned transition of care from pediatrics to adult medicine. Conclusions: This consensus guidelines update should be used to further optimize detection, diagnosis, treatment, and follow-up of children with all forms of CH in the light of the most recent evidence. It should be helpful in convincing health authorities of the benefits of neonatal screening for CH. Further epidemiological and experimental studies are needed to understand the increased incidence of this condition.
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DOI：
10.1111/j.1651-2227.1981.tb06249.x
发表时间：
1981-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
ALM, J;LARSSON, A;ZETTERSTROM, R
通讯作者：
ZETTERSTROM, R
影响因子：
5.8
作者：
Azar-Kolakez, Ahlam;Ecosse, Emmanuel;Leger, Juliane
通讯作者：
Leger, Juliane
影响因子：
6.6
作者：
Alexander, Erik K.;Pearce, Elizabeth N.;Sullivan, Scott
通讯作者：
Sullivan, Scott
影响因子：
3.2
作者：
Bakker, B;Kempers, MJE;Vulsma, T
通讯作者：
Vulsma, T
影响因子：
5.8
作者：
Albert, Benjamin B.;Heather, Natasha;Hofman, Paul L.
通讯作者：
Hofman, Paul L.