Gray matter alterations in early aging: a diffusion magnetic resonance imaging study.
Gray matter alterations in early aging: a diffusion magnetic resonance imaging study.
复制标题
早期衰老中的灰质变化：扩散磁共振成像研究。
DOI：
10.1002/hbm.22441
复制
发表时间：
2014-08
影响因子：
4.8
通讯作者：
Shenton, M. E.
中科院分区：
文献类型：
--
作者：
Rathi, Y.;Pasternak, O.;Savadjiev, P.;Michailovich, O.;Bouix, S.;Kubicki, M.;Westin, C. -F.;Makris, N.;Shenton, M. E.
许多研究已经观察到老化的大脑中神经功能和结构组织的改变。这些来自功能性神经影像学研究的观察结果显示，随着年龄的增长，大脑活动从后脑区转移到前脑区（PASA模型），皮层厚度减少，在额叶中更为明显，其次是顶叶、枕叶和颞叶（逆行模型）。然而，使用扩散MRI （dMRI）来检查灰质中这些神经功能变化背后的结构组织改变的工作很少。因此，我们首次提出在衰老背景下使用弥散MRI检查灰质变化。在这项工作中，我们提出了一种新的基于dMRI的灰质“异质性”测量方法，从扩散MRI的角度阐明了衰老的这些功能和结构模型（PASA和retrogenesis）。在85名受试者（所有男性，年龄15-55岁）的队列中，我们发现年龄与特定大脑区域的“异质性”（一种测量感兴趣区域组织结构布局的方法）之间存在非常高的相关性。我们通过将大脑区域分组为解剖叶和功能区来检查灰质的改变。我们从dMRI数据中发现连接了功能和结构域，并证实了灰质改变的“倒退”假说，同时为衰老的神经功能PASA模型提供了支持，此外还显示了在健康衰老过程中旁边缘区域的保存。
Many studies have observed altered neurofunctional and structural organization in the aging brain. These observations from functional neuroimaging studies show a shift in brain activity from the posterior to the anterior regions with aging (PASA model), as well as a decrease in cortical thickness, which is more pronounced in the frontal lobe followed by the parietal, occipital, and temporal lobes (retrogenesis model). However, very little work has been done using diffusion MRI (dMRI) with respect to examining the structural tissue alterations underlying these neurofunctional changes in the gray matter. Thus, for the first time, we propose to examine gray matter changes using diffusion MRI in the context of aging. In this work, we propose a novel dMRI based measure of gray matter “heterogeneity” that elucidates these functional and structural models (PASA and retrogenesis) of aging from the viewpoint of diffusion MRI. In a cohort of 85 subjects (all males, ages 15–55 years), we show very high correlation between age and “heterogeneity” (a measure of structural layout of tissue in a region-of-interest) in specific brain regions. We examine gray matter alterations by grouping brain regions into anatomical lobes as well as functional zones. Our findings from dMRI data connects the functional and structural domains and confirms the “retrogenesis” hypothesis of gray matter alterations while lending support to the neurofunctional PASA model of aging in addition to showing the preservation of paralimbic areas during healthy aging.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
3.7
作者：
Davis, Simon W.;Dennis, Nancy A.;Cabeza, Roberto
通讯作者：
Cabeza, Roberto
影响因子：
5.7
作者：
Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL
影响因子：
5.7
作者：
Grossman, M;Cooke, A;Gee, J
通讯作者：
Gee, J