Dietary quercetin reduces chemotherapy-induced fatigue in mice.
Dietary quercetin reduces chemotherapy-induced fatigue in mice.
复制标题
DOI：
10.1177/1534735414523315
复制
发表时间：
2014-09
影响因子：
2.9
通讯作者：
Pena MM
中科院分区：
文献类型：
--
作者：
Mahoney SE;Davis JM;Murphy EA;McClellan JL;Pena MM
虽然疲劳是化疗最常见的症状，但目前还没有有效的治疗方法来治疗化疗引起的疲劳（CIF）。我们使用小鼠模型来检查槲皮素对CIF的益处，如通过自愿车轮运行活动测量的，并试图确定槲皮素是否可能与炎症和/或贫血的减少相关。将小鼠分配至4组中的1组：安慰剂-媒介物（Plac-PBS）、安慰剂-5-氟尿嘧啶（Plac-5 FU）、槲皮素-媒介物（Quer-PBS）或槲皮素-5-氟尿嘧啶（Quer-5 FU）。所有小鼠每天注射60 mg/kg 5-FU或磷酸盐缓冲盐水（PBS），持续5天。在5-FU给药前3天和实验期间（即，第-2至14天），在食物中给予槲皮素（0.02%）处理。第二组小鼠在初始注射后第5天和第14天处死，以评估单核细胞趋化蛋白-1（MCP-1）和贫血。注射5-FU后，Plac-5 FU和Quer-5 FU组的自主跑轮次数均减少（P <0.05）。然而，Quer-5 FU组在大约第7天恢复至基线水平，而Plac-5 FU组仍然受到抑制。MCP-1在Plac-5 FU中在14天时显著升高（P <0.001），但在Quer-5 FU中没有观察到变化。5-FU治疗在第5天和第14天均导致贫血;然而，槲皮素在第14天阻断了这种作用（P < .001）。这些结果证明了槲皮素对改善5-FU治疗后自主体力活动恢复的有益作用，这可能与炎症和贫血的减少有关。
While fatigue is the most commonly reported symptom of chemotherapy, there are currently no effective treatments for chemotherapy-induced fatigue (CIF). We used a mouse model to examine the benefits of quercetin on CIF as measured by voluntary wheel running activity and sought to determine whether quercetin may be associated with a decrease in inflammation and/or anemia. Mice were assigned to 1 of 4 groups: placebo-vehicle (Plac-PBS), placebo-5-fluorouracil (Plac-5FU), quercetin-vehicle (Quer-PBS), or quercetin-5-fluorouracil (Quer-5FU). All mice were given a daily injection of either 60 mg/kg of 5-FU or phosphate buffered saline (PBS) for 5 days. Quercetin (0.02%) treatment was administered in the food 3 days prior to 5-FU administration and for the duration of the experiment (ie, days −2 to 14). A second group of mice was sacrificed at 5 and 14 days post initial injection for assessment of monocyte chemoattractant protein-1 (MCP-1) and anemia. Voluntary wheel running was reduced in both the Plac-5FU and Quer-5FU groups following 5-FU injection (P < .05). However, the Quer-5FU group recovered to baseline levels by approximately day 7, whereas the Plac-5FU group remained suppressed. MCP-1 was significantly elevated at 14 days in Plac-5FU (P < .001), but no changes were seen with Quer-5FU. Treatment with 5-FU resulted in anemia at both 5 days and 14 days; however, quercetin blocked this effect at 14 days (P < .001). These results demonstrate the beneficial effect of quercetin on improving recovery of voluntary physical activity following 5-FU treatment, which may be linked to a decrease in inflammation and anemia.
登录
查看更多内容
DOI：
10.1016/j.bbi.2013.11.003
发表时间：
2014-03
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Weymann KB;Wood LJ;Zhu X;Marks DL
通讯作者：
Marks DL
影响因子：
3.6
作者：
Curt, GA
通讯作者：
Curt, GA
影响因子：
7.1
作者：
Chuang, Chia Chi;Martinez, Kristina;McIntosh, Michael K.
通讯作者：
McIntosh, Michael K.
影响因子：
45.3
作者：
Goldstein, David;Bennett, Barbara K.;Lloyd, Andrew R.
通讯作者：
Lloyd, Andrew R.
影响因子：
2.5
作者：
Soares, Danusa Dias;Coimbra, Candido Celso;Marubayashi, Umeko
通讯作者：
Marubayashi, Umeko