Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation.
Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation.
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DOI：
10.1016/j.bandl.2010.01.001
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发表时间：
2010-04
影响因子：
2.5
通讯作者：
Coslett, H. Branch
中科院分区：
文献类型：
--
作者：
Hamilton, Roy H.;Sanders, Linda;Benson, Jennifer;Faseyitan, Olufunsho;Norise, Catherine;Naeser, Margaret;Martin, Paula;Coslett, H. Branch
尽管有证据表明，在完整的右侧额下回接受1hz重复经颅磁刺激（rTMS）的左半球中风和非流利性失语患者在命名方面持续获益，但rTMS对这些患者的影响是否能推广到其他语言能力尚不清楚。我们报告了一名慢性非流利性失语症患者，在5年的时间里，他表现出了诱发命题性言语的稳定缺陷，并在该患者对rTMS反应最佳的部位每天接受1200次1hz rTMS脉冲，持续10天。与先前的研究一致，在对象命名方面有改善，在动作命名方面有统计学上显著的改善。在rTMS后2、6和10个月的图片描述方面，在叙述词和名词的数量、句子长度和封闭类词的使用方面也有改善。与他的基线表现相比，患者在自发性言语的西方失语电池亚量表上表现出显著的改善。这些发现表明，对非流利性失语症患者完整的对侧皮层进行操作可能会导致语言方面的益处，这种益处不仅限于命名，还包括语言产生的其他方面。
Although evidence suggests that patients with left hemisphere strokes and nonfluent aphasia who receive 1 Hz repetitive transcranial magnetic stimulation (rTMS) over the intact right inferior frontal gyrus experience persistent benefits in naming, it remains unclear whether the effects of rTMS in these patients generalize to other language abilities. We report a subject with chronic nonfluent aphasia who showed stable deficits of elicited propositional speech over the course of five years, and received 1200 pulses of 1 Hz rTMS daily for 10 days at a site identified as being optimally responsive to rTMS in this patient. Consistent with prior studies there was improvement in object naming, with a statistically significant improvement in action naming. Improvement was also demonstrated in picture description at 2, 6, and 10 months after rTMS with respect to the number of narrative words and nouns, sentence length, and use of closed class words. Compared to his baseline performance, the patient showed significant improvement on the Western Aphasia Battery subscale for spontaneous speech. These findings suggest that manipulation of the intact contralesional cortex in patients with nonfluent aphasia may result in language benefits that generalize beyond naming to include other aspects of language production.
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影响因子：
9.9
作者：
Mansur, CG;Fregni, F;Pascual-Leone, A
通讯作者：
Pascual-Leone, A
影响因子：
8.3
作者：
Winhuisen, Lutz;Thiel, Alexander;Heiss, Wolf D.
通讯作者：
Heiss, Wolf D.
DOI：
10.1044/jshd.4503.308
发表时间：
1980-01-01
期刊：
JOURNAL OF SPEECH AND HEARING DISORDERS
影响因子：
--
作者：
SHEWAN, CM;KERTESZ, A
通讯作者：
KERTESZ, A
DOI：
10.1037/0278-7393.6.2.174
发表时间：
1980-01-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN LEARNING AND MEMORY
影响因子：
--
作者：
SNODGRASS, JG;VANDERWART, M
通讯作者：
VANDERWART, M
影响因子：
5.3
作者：
Gough, PM;Nobre, AC;Devlin, JT
通讯作者：
Devlin, JT