Modular organization of the mammalian Golgi apparatus.

Modular organization of the mammalian Golgi apparatus.
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DOI:
10.1016/j.ceb.2012.05.009
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发表时间:
2012-08
影响因子:
7.5
通讯作者:
Seemann, Joachim
Seemann, Joachim
中科院分区:
生物学2区
文献类型:
--
作者:
Nakamura, Nobuhiro;Wei, Jen-Hsuan;Seemann, Joachim

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The Golgi apparatus is essential for post-translational modifications and sorting of proteins in the secretory pathway. In addition, it further performs a broad range of specialized functions. This functional diversity is achieved by combining basic morphological modules of cisternae into higher ordered structures. Linking cisternae into stacks that are further connected through tubules into a continuous Golgi ribbon greatly increases its efficiency and expands its repertoire of functions. During cell division, the different modules of the Golgi are inherited by different mechanisms to maintain its functional and morphological composition.
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