Cross-talk between hemidesmosomes and focal contacts: understanding subepidermal blistering diseases.
Cross-talk between hemidesmosomes and focal contacts: understanding subepidermal blistering diseases.
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半桥粒和焦点接触之间的串扰：了解表皮下水疱疾病。
DOI：
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发表时间：
2010
影响因子：
6.5
通讯作者：
Y. Kitajima
中科院分区：
文献类型：
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作者：
Y. Kitajima
由于半桥粒和焦点接触（FC）在表皮伤口愈合和表皮下起泡疾病的发病机制中起着重要作用，因此了解它们在组装和拆卸调节中的串扰尤为重要。在这个问题上，Ozawa等人证明，半桥粒富集蛋白复合物（HPC）和FC动力学在角质形成细胞中受到密切的共同调节，通过采用HaCat细胞表达荧光蛋白标记的β 4整联蛋白和α-辅肌动蛋白作为HPC和FC的标志物进行迁移。
Because hemidesmosomes and focal contacts (FCs) play major roles in epidermal wound healing and in the pathogenesis of subepidermal blistering diseases, it is of particular importance to understand their cross-talk in the regulation of their assembly and disassembly. In this issue, Ozawa et al. demonstrate that hemidesmosome-enriched protein complex (HPC) and FC dynamics are tightly coregulated in keratinocytes undergoing migration by employing HaCat cells that express fluorescent protein-tagged beta4 integrin and alpha-actinin as markers of HPCs and FCs.
影响因子：
7.3
作者：
T. Yin;K. Green
通讯作者：
T. Yin;K. Green